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Phenotypic and genotypic characteriz...

Wang, Ying.

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Phenotypic and genotypic characterization of nephropathy in Chinese patients with type 2 diabetes.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Phenotypic and genotypic characterization of nephropathy in Chinese patients with type 2 diabetes./
Author:	Wang, Ying.
Description:	300 p.
Notes:	Source: Dissertation Abstracts International, Volume: 64-07, Section: B, page: 3078.
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3099308

Phenotypic and genotypic characterization of nephropathy in Chinese patients with type 2 diabetes.
Wang, Ying.

Phenotypic and genotypic characterization of nephropathy in Chinese patients with type 2 diabetes. - 300 p.

Source: Dissertation Abstracts International, Volume: 64-07, Section: B, page: 3078.

Thesis (Ph.D.)--Chinese University of Hong Kong (People's Republic of China), 2003.

Diabetic microvascular complications are major causes of morbidity and mortality in diabetic patients. To elucidate the phenotypic and genotypic characterizations of nephropathy in Chinese diabetic population, I have investigated 1041 Chinese Type 2 diabetic patients with or without nephropathy using cross-sectional, prospective and case-control study designs. In this series of studies, the associations of diabetic nephropathy with the angiotensin-converting enzyme (ACE) gene insertion/deletion polymorphism, angiotensinogen (AGT) gene M23 5T polymorphism, aldose reductase (ALR2) gene 5<super>′</super>-(CA) n microsatellite and promoter C-106T polymorphisms as well as tumor necrosis factor alpha (TNF-α) gene G-308A polymorphism were investigated. The effects of gene-modifiable risk factor and gene-gene interactions on the development of diabetic nephropathy were also explored.

Phenotypic and genotypic characterization of nephropathy in Chinese patients with type 2 diabetes.
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035 $a (UnM)AAI3099308
035 $a AAI3099308
040 $a UnM $c UnM
100 1 $a Wang, Ying. $3 558207
245 1 0 $a Phenotypic and genotypic characterization of nephropathy in Chinese patients with type 2 diabetes.
300 $a 300 p.
500 $a Source: Dissertation Abstracts International, Volume: 64-07, Section: B, page: 3078.
500 $a Supervisor: Juliana C. N. Chan.
502 $a Thesis (Ph.D.)--Chinese University of Hong Kong (People's Republic of China), 2003.
520 $a Diabetic microvascular complications are major causes of morbidity and mortality in diabetic patients. To elucidate the phenotypic and genotypic characterizations of nephropathy in Chinese diabetic population, I have investigated 1041 Chinese Type 2 diabetic patients with or without nephropathy using cross-sectional, prospective and case-control study designs. In this series of studies, the associations of diabetic nephropathy with the angiotensin-converting enzyme (ACE) gene insertion/deletion polymorphism, angiotensinogen (AGT) gene M23 5T polymorphism, aldose reductase (ALR2) gene 5<super>′</super>-(CA) n microsatellite and promoter C-106T polymorphisms as well as tumor necrosis factor alpha (TNF-α) gene G-308A polymorphism were investigated. The effects of gene-modifiable risk factor and gene-gene interactions on the development of diabetic nephropathy were also explored.
520 $a The key findings are as follows: (1) Investigation of phenotypic characteristics of diabetic nephropathy confirmed other investigators' work. Male gender, poor glycemia control, hypertension, obesity, dyslipidaemia, presence of retinopathy, coronary heart disease and peripheral vascular disease were independent predictors for nephropathy. Long term use of RAS inhibitors was an independent protective factor against progression to renal endpoint. The coexistence of both nephropathy and retinopathy was associated with the highest mortality rate compared to presence of either one or none of the two complications. (2) The TT genotype of angiotensinogen (AGT) gene M235T polymorphisms interacted with hypertension, dyslipidaemia and obesity to increase the risk for diabetic nephropathy. (3) The D allele of angiotensin-converting enzyme (ACE) gene Insertion/Deletion (I/D) polymorphism interacted with hypertension and dyslipidaemia to increase the risk for diabetic nephropathy. The DD genotype was an independent predictor for renal events. (4) The z-2 allele of 5<super> ′</super>-(CA)n polymorphism and T allele of C-106T polymorphism of aldose reductase (ALR2) gene were associated with diabetic nephropathy. These two alleles interacted with poor glycemic control to increase the risk for diabetic nephropathy. The z+6 allele of 5<super>′</super>-(CA) n polymorphism was a protective allele for nephropathy. (5) The GG genotype of tumor necrosis factor alpha (TNF-α) G-308A polymorphism interacted with obesity to increase the risk for diabetic nephropathy. (6) The interactions among AGT gene M235T, ACE gene I/D, ALR2 gene 5<super>′ </super>-(CA)n and C-106T, and TNF-α gene G-308A polymorphisms contribute to increased risk of diabetic nephropathy and possibly renal events and all cause death
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3099308