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Investigation of cognitive impairmen...

Stanonik, Mateja de Leonni.

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Investigation of cognitive impairments using functional magnetic resonance imaging (fMRI) and positron emission tomography (PET) in patients with mild Alzheimer's disease.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Investigation of cognitive impairments using functional magnetic resonance imaging (fMRI) and positron emission tomography (PET) in patients with mild Alzheimer's disease./
作者:	Stanonik, Mateja de Leonni.
面頁冊數:	369 p.
附註:	Source: Dissertation Abstracts International, Volume: 63-08, Section: B, page: 3682.
Contained By:	Dissertation Abstracts International63-08B.
標題:	Health Sciences, Radiology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3062332
ISBN:	0493782931

Investigation of cognitive impairments using functional magnetic resonance imaging (fMRI) and positron emission tomography (PET) in patients with mild Alzheimer's disease.
Stanonik, Mateja de Leonni.

Investigation of cognitive impairments using functional magnetic resonance imaging (fMRI) and positron emission tomography (PET) in patients with mild Alzheimer's disease. - 369 p.

Source: Dissertation Abstracts International, Volume: 63-08, Section: B, page: 3682.

Thesis (Ph.D.)--The University of Tennessee, 2002.

Early recognition of Alzheimer's disease (AD) is increasingly important as new medical treatments become available. The purpose of this study was to examine the relationship between the regional cerebral glucose uptake as well as increased blood oxygen levels and the biological substrates, which underlie impairments in selective attention and anosognosia (lack of awareness of disease). We report on new functional MRI and FDG PET techniques designed to image mild AD using a cognitive stressor for selective attention.

ISBN: 0493782931Subjects--Topical Terms:

1019076
Health Sciences, Radiology.

Investigation of cognitive impairments using functional magnetic resonance imaging (fMRI) and positron emission tomography (PET) in patients with mild Alzheimer's disease.
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245 1 0 $a Investigation of cognitive impairments using functional magnetic resonance imaging (fMRI) and positron emission tomography (PET) in patients with mild Alzheimer's disease.
300 $a 369 p.
500 $a Source: Dissertation Abstracts International, Volume: 63-08, Section: B, page: 3682.
500 $a Major Professor: John H. Dougherty.
502 $a Thesis (Ph.D.)--The University of Tennessee, 2002.
520 $a Early recognition of Alzheimer's disease (AD) is increasingly important as new medical treatments become available. The purpose of this study was to examine the relationship between the regional cerebral glucose uptake as well as increased blood oxygen levels and the biological substrates, which underlie impairments in selective attention and anosognosia (lack of awareness of disease). We report on new functional MRI and FDG PET techniques designed to image mild AD using a cognitive stressor for selective attention.
520 $a Twenty three subjects---10 patients with probable AD (NINCDS-ADRDA criteria) and 13 normal age-matched volunteers were examined. fMRI scans and FDG PET scans were performed using the Counting Stroop Test, a selective attention task believed to trigger neurobiological substrates responsible for affording humans to choose biologically important stimuli successfully. Anosognosia severity was measured using the Anosognosia Questionnaire.
520 $a The neuroimaging results suggest morphological and functional discordance of impairments in the earliest stages of AD. FMRI findings showed increased activations in the medial and inferior occipital lobes, the right posterior parietal lobe, the left caudate nucleus, the right thalamus, the inferior and medial frontal lobe bilaterally as well as the insular cortex bilaterally. Qualitative impression of FDG PET scans indicated a general pattern of temporal and biparietal decrease in glucose uptake in most of the mild AD patients. Subtracting baseline from activation FDG-PET images, focal decrease in glucose metabolism was determined in the following areas: superior ACC bilaterally, lateral and medial thalamus, superior colliculi, the right dorsolateral prefrontal areas, and superior posterior parietal cortices bilaterally.
520 $a Six out of 10 mild AD patients showed moderate to severe anosognosia (mean difference 0.87, p < 0.02). When activity in the ACC was compared between those mild AD patients with and without anosognosia, both quantitative fMRI and FDG PET analyses showed decreased functional and metabolic responses in those patients who were generally not aware of their cognitive deficiencies. The functional hypoactivity of the ACC of those mild AD patients with anosognosia suggests that anosognosia may denote a specific cognitive abnormality of selective attention in mild AD patients.
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790 1 0 $a Dougherty, John H., $e advisor
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791 $a Ph.D.
792 $a 2002
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