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Regulation of dendritic cell biology...

Frleta, Davor.

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Regulation of dendritic cell biology in vitro and in vivo with biological response modifiers.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Regulation of dendritic cell biology in vitro and in vivo with biological response modifiers./
Author:	Frleta, Davor.
Description:	231 p.
Notes:	Source: Dissertation Abstracts International, Volume: 65-03, Section: B, page: 1232.
Contained By:	Dissertation Abstracts International65-03B.
Subject:	Health Sciences, Immunology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3126252
ISBN:	0496735381

Regulation of dendritic cell biology in vitro and in vivo with biological response modifiers.
Frleta, Davor.

Regulation of dendritic cell biology in vitro and in vivo with biological response modifiers. - 231 p.

Source: Dissertation Abstracts International, Volume: 65-03, Section: B, page: 1232.

Thesis (Ph.D.)--Dartmouth College, 2004.

Dendritic cells (DCs) are professional antigen-presenting cells (APCs) that regulate antigen-specific T cell activation or tolerance. The maturation state of DCs is critical since immature DCs are believed to induce T cell tolerance whereas mature DCs stimulate T cell activation. DC maturation is primarily characterized by decreased antigen-uptake and up-regulation of MHC class I, II, and costimulatory molecules necessary for T cell activation. Many different stimuli induce DC maturation either in vitro or in vivo. The goal of these studies is to extend our understanding of DC biology in vitro and in vivo in response to different biological response modifiers.

ISBN: 0496735381Subjects--Topical Terms:

1017716
Health Sciences, Immunology.

Regulation of dendritic cell biology in vitro and in vivo with biological response modifiers.
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035 $a (UnM)AAI3126252
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100 1 $a Frleta, Davor. $3 1939164
245 1 0 $a Regulation of dendritic cell biology in vitro and in vivo with biological response modifiers.
300 $a 231 p.
500 $a Source: Dissertation Abstracts International, Volume: 65-03, Section: B, page: 1232.
500 $a Chair: James D. Gorham.
502 $a Thesis (Ph.D.)--Dartmouth College, 2004.
520 $a Dendritic cells (DCs) are professional antigen-presenting cells (APCs) that regulate antigen-specific T cell activation or tolerance. The maturation state of DCs is critical since immature DCs are believed to induce T cell tolerance whereas mature DCs stimulate T cell activation. DC maturation is primarily characterized by decreased antigen-uptake and up-regulation of MHC class I, II, and costimulatory molecules necessary for T cell activation. Many different stimuli induce DC maturation either in vitro or in vivo. The goal of these studies is to extend our understanding of DC biology in vitro and in vivo in response to different biological response modifiers.
520 $a These studies reveal differences in expression kinetics of MHC class II and costimulatory molecules between both splenic and draining lymph node (DLN) DCs in response to various maturation stimuli. In regards to studies with DLN DCs, it was hypothesized that combinations of CD40 and TLR/adjuvant stimulation that prolong DC persistence and augment maturation status would correlate with enhanced antigen-specific T cell immunity. However, the differences in mature DC phenotype in response to different biological modifiers do not correlate with differences in antigen-specific T cell activation or with differences in tumor immunity. We also examine the cross-talk between CD40 agonist and TLR4 and show that CD40 stimulation of DCs up-regulates TLR4-MD2, the receptor that recognizes lipopolysaccharide (LPS).
520 $a Overall, our studies highlight how DC biology is regulated both in vitro and in vivo. These findings will be important for DC-based vaccine design as well as our understanding of the DC response to pathogenic and cellular-derived components.
590 $a School code: 0059.
650 4 $a Health Sciences, Immunology. $3 1017716
650 4 $a Biology, Cell. $3 1017686
690 $a 0982
690 $a 0379
710 2 0 $a Dartmouth College. $3 1025074
773 0 $t Dissertation Abstracts International $g 65-03B.
790 1 0 $a Gorham, James D., $e advisor
790 $a 0059
791 $a Ph.D.
792 $a 2004
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3126252