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Testosterone-mediated immune functio...

Muehlenbein, Michael Paul.

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Testosterone-mediated immune function: An energetic allocation mechanism evaluated in human and non-human primate males.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Testosterone-mediated immune function: An energetic allocation mechanism evaluated in human and non-human primate males./
Author:	Muehlenbein, Michael Paul.
Description:	287 p.
Notes:	Source: Dissertation Abstracts International, Volume: 65-03, Section: A, page: 1012.
Contained By:	Dissertation Abstracts International65-03A.
Subject:	Anthropology, Physical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3125268
ISBN:	0496725580

Testosterone-mediated immune function: An energetic allocation mechanism evaluated in human and non-human primate males.
Muehlenbein, Michael Paul.

Testosterone-mediated immune function: An energetic allocation mechanism evaluated in human and non-human primate males. - 287 p.

Source: Dissertation Abstracts International, Volume: 65-03, Section: A, page: 1012.

Thesis (Ph.D.)--Yale University, 2004.

Recent advances in life history theory within biological anthropology have provided new insights into the potential selection pressures that were instrumental in the evolution of human and non-human primate males. However, gaps remain in our understanding of how primate males regulate and allocate energetic resources between survivorship and reproductive effort. Defense against parasitic infection is an important force shaping life history evolution. Proper performance of host immune responses is influenced by many physiological systems, including steroid hormones that regulate reproductive function and stress responses. Because testosterone modulates immune, reproductive, and somatic metabolic functions, assessing interactions between testosterone and immune factors during infection may be insightful.

ISBN: 0496725580Subjects--Topical Terms:

877524
Anthropology, Physical.

Testosterone-mediated immune function: An energetic allocation mechanism evaluated in human and non-human primate males.
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100 1 $a Muehlenbein, Michael Paul. $3 1939143
245 1 0 $a Testosterone-mediated immune function: An energetic allocation mechanism evaluated in human and non-human primate males.
300 $a 287 p.
500 $a Source: Dissertation Abstracts International, Volume: 65-03, Section: A, page: 1012.
500 $a Director: Richard Gutierrez Bribiescas.
502 $a Thesis (Ph.D.)--Yale University, 2004.
520 $a Recent advances in life history theory within biological anthropology have provided new insights into the potential selection pressures that were instrumental in the evolution of human and non-human primate males. However, gaps remain in our understanding of how primate males regulate and allocate energetic resources between survivorship and reproductive effort. Defense against parasitic infection is an important force shaping life history evolution. Proper performance of host immune responses is influenced by many physiological systems, including steroid hormones that regulate reproductive function and stress responses. Because testosterone modulates immune, reproductive, and somatic metabolic functions, assessing interactions between testosterone and immune factors during infection may be insightful.
520 $a In this thesis, I propose the "Immunosomatic Metabolic Diversion Hypothesis" (IMDH) which states that diversion of metabolic energy to support immune function during infection reduces the energy available for reproductive effort (i.e., muscle mass to aid in mate attraction and competition with conspecifics for access to mates). Maintaining high testosterone levels in order to bolster reproductive effort could induce fitness costs because it may cause immunosuppression and increase morbidity and mortality. The IMDH therefore provides an evolutionary framework for evaluating testosterone-mediated immunosuppression.
520 $a Testosterone-immunocompetence associations have been assessed in human and non-human primates less frequently compared to other species. Thus, investigating the immunomodulatory actions of testosterone in suitable human and non-human primate models in vivo allows greater understanding of the evolutionary significance of immunoendocrine interactions and provides a unique life-historical perspective on human and non-human primate immune functions. Therefore, I evaluated associations between immunocompetence and testosterone levels using three different disease models: gastrointestinal parasite infections in wild male chimpanzees, malarial infection in human Hondurans, and Venezuelan Equine Encephalitis (VEE) virus infection in captive male long-tailed macaques. Results of these projects were consistent with the hypotheses that: (1) testosterone is associated with gastrointestinal helminth infections in wild male chimpanzees; (2) peripheral testosterone levels are decreased during protozoan and viral infections in male humans and macaque, respectively; (3) testosterone levels are positively associated with parasitemia in human male malarial infections; and (4) male macaques with higher baseline testosterone levels exhibit higher VEE viremia levels when exposed.
590 $a School code: 0265.
650 4 $a Anthropology, Physical. $3 877524
650 4 $a Health Sciences, Immunology. $3 1017716
650 4 $a Biology, Microbiology. $3 1017734
690 $a 0327
690 $a 0982
690 $a 0410
710 2 0 $a Yale University. $3 515640
773 0 $t Dissertation Abstracts International $g 65-03A.
790 1 0 $a Bribiescas, Richard Gutierrez, $e advisor
790 $a 0265
791 $a Ph.D.
792 $a 2004
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3125268