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Homeostatic maintenance of memory CD...

Becker, Todd C.

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Homeostatic maintenance of memory CD8 T cells.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Homeostatic maintenance of memory CD8 T cells./
Author:	Becker, Todd C.
Description:	151 p.
Notes:	Source: Dissertation Abstracts International, Volume: 65-02, Section: B, page: 0642.
Contained By:	Dissertation Abstracts International65-02B.
Subject:	Health Sciences, Immunology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3123309
ISBN:	0496706209

Homeostatic maintenance of memory CD8 T cells.
Becker, Todd C.

Homeostatic maintenance of memory CD8 T cells. - 151 p.

Source: Dissertation Abstracts International, Volume: 65-02, Section: B, page: 0642.

Thesis (Ph.D.)--Emory University, 2004.

Following an acute viral infection, memory CD8 T cells are established that can mediate life-long immunological protection. The long-term maintenance of memory CD8 T cells is dependent upon a process of proliferative renewal that has been termed "homeostatic proliferation." In this study, we have examined the signals that promote memory CD8 T cell homeostatic proliferation and stable long-term maintenance. We found that the cytokine IL-15 was absolutely required for homeostatic proliferation to maintain populations of memory cells for long periods of time. We identified a bone marrow-derived cell type as the source of IL-15, and found that expression of the high-affinity IL-15Ralpha was dispensable on T cells but was required on a non-T cell population to promote homeostatic proliferation. This suggested an indirect mode of action for IL-15, and in vitro and in vivo studies implicated dendritic cells (DCs) as mediators of IL-15 signaling to memory cells. We next examined the in vivo distribution of memory cells and identified the bone marrow as the most active site of homeostatic proliferation of in intact immune mice and of antigen-independent bystander proliferation for memory CD8 T cells. Our final study addressed the regulation of the T cell compartment, specifically which T cell subsets are co-regulated and which are independently regulated. We found that CD4 and CD8 T cells occupy overlapping niches as has been described by others. However, we found that while the naive T cell compartment seems to be regulated by competition for limiting resources, the memory cell compartment is not under strict regulatory control as others have reported. These findings suggest the need to revise our concept of the "immunological niche."

ISBN: 0496706209Subjects--Topical Terms:

1017716
Health Sciences, Immunology.

Homeostatic maintenance of memory CD8 T cells.
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245 1 0 $a Homeostatic maintenance of memory CD8 T cells.
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500 $a Source: Dissertation Abstracts International, Volume: 65-02, Section: B, page: 0642.
500 $a Adviser: Rafi Ahmed.
502 $a Thesis (Ph.D.)--Emory University, 2004.
520 $a Following an acute viral infection, memory CD8 T cells are established that can mediate life-long immunological protection. The long-term maintenance of memory CD8 T cells is dependent upon a process of proliferative renewal that has been termed "homeostatic proliferation." In this study, we have examined the signals that promote memory CD8 T cell homeostatic proliferation and stable long-term maintenance. We found that the cytokine IL-15 was absolutely required for homeostatic proliferation to maintain populations of memory cells for long periods of time. We identified a bone marrow-derived cell type as the source of IL-15, and found that expression of the high-affinity IL-15Ralpha was dispensable on T cells but was required on a non-T cell population to promote homeostatic proliferation. This suggested an indirect mode of action for IL-15, and in vitro and in vivo studies implicated dendritic cells (DCs) as mediators of IL-15 signaling to memory cells. We next examined the in vivo distribution of memory cells and identified the bone marrow as the most active site of homeostatic proliferation of in intact immune mice and of antigen-independent bystander proliferation for memory CD8 T cells. Our final study addressed the regulation of the T cell compartment, specifically which T cell subsets are co-regulated and which are independently regulated. We found that CD4 and CD8 T cells occupy overlapping niches as has been described by others. However, we found that while the naive T cell compartment seems to be regulated by competition for limiting resources, the memory cell compartment is not under strict regulatory control as others have reported. These findings suggest the need to revise our concept of the "immunological niche."
590 $a School code: 0665.
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