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New development of theory and applic...

Zhou, Marilyn Xiaohong.

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New development of theory and application in capillary electrophoresis: Extended dissociation model for predicting electroosmotic mobility, correction of electrokinetic sampling bias, and enantiomeric separations.

Record Type:	Electronic resources : Monograph/item
Title/Author:	New development of theory and application in capillary electrophoresis: Extended dissociation model for predicting electroosmotic mobility, correction of electrokinetic sampling bias, and enantiomeric separations./
Author:	Zhou, Marilyn Xiaohong.
Description:	228 p.
Notes:	Source: Dissertation Abstracts International, Volume: 65-01, Section: B, page: 0199.
Contained By:	Dissertation Abstracts International65-01B.
Subject:	Chemistry, Analytical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3119332
ISBN:	0496667300

New development of theory and application in capillary electrophoresis: Extended dissociation model for predicting electroosmotic mobility, correction of electrokinetic sampling bias, and enantiomeric separations.
Zhou, Marilyn Xiaohong.

New development of theory and application in capillary electrophoresis: Extended dissociation model for predicting electroosmotic mobility, correction of electrokinetic sampling bias, and enantiomeric separations. - 228 p.

Source: Dissertation Abstracts International, Volume: 65-01, Section: B, page: 0199.

Thesis (Ph.D.)--Drexel University, 2004.

Although the theoretical research of capillary electrophoresis (CE) is quite active in past twenty years and the technology of capillary electrophoresis has been accepted and widely used in chemical and pharmaceutical industries, quantitative control of electroosmotic mobility, the driving separation force in capillary electrophoresis, is still very limited. So far, there was no thorough study conducted on the quantitative control of electroosmotic mobility from theoretical approach. In this thesis, a new equilibrium ion adsorption model was developed based upon the chemical kinetic theory and Langmuir isotherm theory. This theory was successfully confirmed by the experimental results.

ISBN: 0496667300Subjects--Topical Terms:

586156
Chemistry, Analytical.

New development of theory and application in capillary electrophoresis: Extended dissociation model for predicting electroosmotic mobility, correction of electrokinetic sampling bias, and enantiomeric separations.
LDR:03181nmm 2200313 4500 001 1851225
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020 $a 0496667300
035 $a (UnM)AAI3119332
035 $a AAI3119332
040 $a UnM $c UnM
100 1 $a Zhou, Marilyn Xiaohong. $3 1939120
245 1 0 $a New development of theory and application in capillary electrophoresis: Extended dissociation model for predicting electroosmotic mobility, correction of electrokinetic sampling bias, and enantiomeric separations.
300 $a 228 p.
500 $a Source: Dissertation Abstracts International, Volume: 65-01, Section: B, page: 0199.
500 $a Adviser: Joe Preston Foley.
502 $a Thesis (Ph.D.)--Drexel University, 2004.
520 $a Although the theoretical research of capillary electrophoresis (CE) is quite active in past twenty years and the technology of capillary electrophoresis has been accepted and widely used in chemical and pharmaceutical industries, quantitative control of electroosmotic mobility, the driving separation force in capillary electrophoresis, is still very limited. So far, there was no thorough study conducted on the quantitative control of electroosmotic mobility from theoretical approach. In this thesis, a new equilibrium ion adsorption model was developed based upon the chemical kinetic theory and Langmuir isotherm theory. This theory was successfully confirmed by the experimental results.
520 $a In Chapter 1, a historical review of the development of capillary electrophoresis technology, the development of theories involved in CE, and the landmarks of the application of CE are presented.
520 $a In Chapter 2, the detailed derivation of the equilibrium ion adsorption model is provided. In addition, the theoretical model was verified by using three types of buffer systems: buffers containing monovalent cations only; buffers containing multiple cations; and buffers containing cations and neutral additives.
520 $a Chapter 3 presents the study of suppressing the electroosmotic mobility by using multiply charged cations along with the microemulsion system for the purpose of dual opposite injection, which further qualitatively confirmed the theoretical model described in Chapter 2. An improvement of bias correction factor for an electrokinetic injection of sample was also presented.
520 $a Chapter 4 presents a development of a new analytical method for the quantitation of chiral impurities in sertraline hydrochloride, a therapeutic drug. The highly sulfated gamma-cyclodextrin was used as the chiral selector. The method is capable to separate and accurately quantitate the stereoisomeric impurities at 0.1% of the active. In addition, the van't Hoff plot demonstrates a non-linear relationship between ln alpha and 1/T. The effect of temperature on separation also supported by the theoretical model described in Chapter 2.
590 $a School code: 0065.
650 4 $a Chemistry, Analytical. $3 586156
690 $a 0486
710 2 0 $a Drexel University. $3 1018434
773 0 $t Dissertation Abstracts International $g 65-01B.
790 1 0 $a Foley, Joe Preston, $e advisor
790 $a 0065
791 $a Ph.D.
792 $a 2004
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3119332