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Regulation of sialic acid metabolism.

Kalivoda, Kathryn Antoinette.

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Regulation of sialic acid metabolism.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Regulation of sialic acid metabolism./
Author:	Kalivoda, Kathryn Antoinette.
Description:	136 p.
Notes:	Source: Dissertation Abstracts International, Volume: 65-04, Section: B, page: 1691.
Contained By:	Dissertation Abstracts International65-04B.
Subject:	Biology, Molecular. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3130946
ISBN:	0496781944

Regulation of sialic acid metabolism.
Kalivoda, Kathryn Antoinette.

Regulation of sialic acid metabolism. - 136 p.

Source: Dissertation Abstracts International, Volume: 65-04, Section: B, page: 1691.

Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2004.

Sialic acids (N&barbelow;-a&barbelow;cyln&barbelow;euraminates) are unique nine-carbon monosaccharides primarily synthesized by higher eukaryotes, contributing to immune regulation and self-discrimination. In Escherichia coli and some other certain bacteria, sialic acids are used as sole carbon and nitrogen sources in addition to their functions as molecular mimics in the evasion of host defenses. In pathogens that either synthesize sialic acids de novo or scavenge it from their hosts, regulating the metabolic decision to activate or degrade sialic acid is critical to the host-pathogen interaction.

ISBN: 0496781944Subjects--Topical Terms:

1017719
Biology, Molecular.

Regulation of sialic acid metabolism.
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020 $a 0496781944
035 $a (UnM)AAI3130946
035 $a AAI3130946
040 $a UnM $c UnM
100 1 $a Kalivoda, Kathryn Antoinette. $3 1935469
245 1 0 $a Regulation of sialic acid metabolism.
300 $a 136 p.
500 $a Source: Dissertation Abstracts International, Volume: 65-04, Section: B, page: 1691.
500 $a Adviser: Eric R. Vimr.
502 $a Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2004.
520 $a Sialic acids (N&barbelow;-a&barbelow;cyln&barbelow;euraminates) are unique nine-carbon monosaccharides primarily synthesized by higher eukaryotes, contributing to immune regulation and self-discrimination. In Escherichia coli and some other certain bacteria, sialic acids are used as sole carbon and nitrogen sources in addition to their functions as molecular mimics in the evasion of host defenses. In pathogens that either synthesize sialic acids de novo or scavenge it from their hosts, regulating the metabolic decision to activate or degrade sialic acid is critical to the host-pathogen interaction.
520 $a The GntR family of DNA binding proteins represents a diverse set of transcriptional regulators, wherein the FadR subfamily proteins recognize the sequence nnntnGTnnnACnannn. In Escherichia coli, the nanATEKyhcH operon encodes enzymes for the catabolism of exogenous sialic acids: permease ( nanT); aldolase (nanA); kinase (nanK); epimerase (nanE) and a polypeptide (YhcH) of unknown function. The nan operon is transcriptionally regulated by a repressor protein (NanR) that appears to recognize a region containing three tandem hexanucleotide repeats, 5'-GGTATAacaGGTATAaaGGTATA-3 ', in the nan operator located 5' to nanA.
520 $a This study focuses on the isolation and characterization of the repressor of the nan operon, NanR, as well as determining the mechanism NanR uses for achieving specificity by identifying critical residues in the operator DNA, and identifying amino acid residues of NanR that are important for binding. The evidence presented leads to the proposal of three models that are used to define the unique method by which NanR binds its target DNA.
520 $a In bacteria, sialic acids act as virulence factors for certain pathogens, and have been determined to play an important role in the establishment of many disease states. Therefore, studying the intricacies of sialic acid metabolism and its regulation provide a foundation for studying several medically important host-pathogen interactions.
590 $a School code: 0090.
650 4 $a Biology, Molecular. $3 1017719
650 4 $a Biology, Microbiology. $3 1017734
690 $a 0307
690 $a 0410
710 2 0 $a University of Illinois at Urbana-Champaign. $3 626646
773 0 $t Dissertation Abstracts International $g 65-04B.
790 1 0 $a Vimr, Eric R., $e advisor
790 $a 0090
791 $a Ph.D.
792 $a 2004
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3130946