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Aerobic exercise attenuates asthmati...

Pastva, Amy M.

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Aerobic exercise attenuates asthmatic airway inflammation.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Aerobic exercise attenuates asthmatic airway inflammation./
作者:	Pastva, Amy M.
面頁冊數:	141 p.
附註:	Source: Dissertation Abstracts International, Volume: 65-10, Section: B, page: 5091.
Contained By:	Dissertation Abstracts International65-10B.
標題:	Health Sciences, Pathology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3149783
ISBN:	0496092561

Aerobic exercise attenuates asthmatic airway inflammation.
Pastva, Amy M.

Aerobic exercise attenuates asthmatic airway inflammation. - 141 p.

Source: Dissertation Abstracts International, Volume: 65-10, Section: B, page: 5091.

Thesis (Ph.D.)--The University of Alabama at Birmingham, 2004.

Asthma has increased in prevalence, morbidity, and mortality over the past 20 years. Recent reports indicate that aerobic exercise improves the overall health of patients with respiratory diseases, including asthma; however, documented alterations in the asthmatic response as well as the mechanisms that underlie such alterations remain ill-defined. It is well documented that exercise profoundly influences the immune system; such effects may be caused by an exercise-induced release of endogenous glucocorticoids (GCs). GC hormone acts as an anti-inflammatory agent through binding to the glucocorticoid receptor (GR) and subsequent alteration of transcriptional events; such events can include the inhibition of the transcription factor NF-kappaB. Activated NF-kappaB regulates the expression of a variety of genes that encode inflammatory mediators and has been implicated in the pathogenesis of asthma.

ISBN: 0496092561Subjects--Topical Terms:

1017854
Health Sciences, Pathology.

Aerobic exercise attenuates asthmatic airway inflammation.
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245 1 0 $a Aerobic exercise attenuates asthmatic airway inflammation.
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500 $a Source: Dissertation Abstracts International, Volume: 65-10, Section: B, page: 5091.
500 $a Chair: Lisa M. Schwiebert.
502 $a Thesis (Ph.D.)--The University of Alabama at Birmingham, 2004.
520 $a Asthma has increased in prevalence, morbidity, and mortality over the past 20 years. Recent reports indicate that aerobic exercise improves the overall health of patients with respiratory diseases, including asthma; however, documented alterations in the asthmatic response as well as the mechanisms that underlie such alterations remain ill-defined. It is well documented that exercise profoundly influences the immune system; such effects may be caused by an exercise-induced release of endogenous glucocorticoids (GCs). GC hormone acts as an anti-inflammatory agent through binding to the glucocorticoid receptor (GR) and subsequent alteration of transcriptional events; such events can include the inhibition of the transcription factor NF-kappaB. Activated NF-kappaB regulates the expression of a variety of genes that encode inflammatory mediators and has been implicated in the pathogenesis of asthma.
520 $a Given that the increase in prevalence of asthma is a major public health concern, research that explores asthma-related therapies is vital. The hypothesis of this dissertation was that moderate intensity aerobic exercise attenuates atopic inflammatory responses in a mouse model of chronic asthma via a mechanism that involves NF-kappaB, the endogenous mouse GC, corticosterone, and the GR. Specifically, the aims that tested this hypothesis included the following: (1) Characterize the effect of aerobic exercise on inflammatory responses within the atopic asthmatic lung, and (2) examine the mechanism that underlies exercise-mediated attenuation of the atopic asthmatic response. Work presented in this dissertation demonstrates that moderate aerobic exercise training decreases asthma-related lung inflammatory responses, including leukocyte infiltration, chemokine production, and adhesion molecule expression. Furthermore, these data suggest that moderate exercise exerts such anti-inflammatory effects via a mechanism that involves modulation of NF-kappaB activation, endogenous corticosterone production, and GR activation. Novel data gathered through the studies discussed in this dissertation demonstrate the therapeutic potential of aerobic exercise in the management of asthma in humans.
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