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Identification and characterization ...

Katic, Iskra.

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Identification and characterization of genes that affect lin-12 activity in Caenorhabditis elegans.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Identification and characterization of genes that affect lin-12 activity in Caenorhabditis elegans./
Author:	Katic, Iskra.
Description:	147 p.
Notes:	Source: Dissertation Abstracts International, Volume: 66-01, Section: B, page: 0074.
Contained By:	Dissertation Abstracts International66-01B.
Subject:	Biology, Genetics. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3159744
ISBN:	0496928708

Identification and characterization of genes that affect lin-12 activity in Caenorhabditis elegans.
Katic, Iskra.

Identification and characterization of genes that affect lin-12 activity in Caenorhabditis elegans. - 147 p.

Source: Dissertation Abstracts International, Volume: 66-01, Section: B, page: 0074.

Thesis (Ph.D.)--Columbia University, 2005.

The LIN-12/Notch receptors mediate many intracellular signaling events that specify cell fates during animal development. Screens for s&barbelow;uppressors or e&barbelow;nhancers of l&barbelow;in-12 alleles ( sel genes) have identified key components of the LIN-12/Notch signaling pathway.

ISBN: 0496928708Subjects--Topical Terms:

1017730
Biology, Genetics.

Identification and characterization of genes that affect lin-12 activity in Caenorhabditis elegans.
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100 1 $a Katic, Iskra. $3 1933113
245 1 0 $a Identification and characterization of genes that affect lin-12 activity in Caenorhabditis elegans.
300 $a 147 p.
500 $a Source: Dissertation Abstracts International, Volume: 66-01, Section: B, page: 0074.
500 $a Adviser: Iva Greenwald.
502 $a Thesis (Ph.D.)--Columbia University, 2005.
520 $a The LIN-12/Notch receptors mediate many intracellular signaling events that specify cell fates during animal development. Screens for s&barbelow;uppressors or e&barbelow;nhancers of l&barbelow;in-12 alleles ( sel genes) have identified key components of the LIN-12/Notch signaling pathway.
520 $a In this thesis, evidence is provided that the gene sel-6 is a positive regulator of lin-12 activity based on its ability to suppress defects associated with hypermorphic alleles of lin-12 as well as enhance the effects of partially reduced lin-12 activity. sel-6 appears to have multiple roles during C. elegans development, as loss of sel-6 activity causes a broad range of phenotypes, including embryonic and larval lethality. SEL-6 is a large protein containing a putative ATPase domain, and has highly conserved orthologs in higher eukaryotes, including insects and mammals.
520 $a In addition, a screen for suppressors of the egg-laying defect associated with a lin-12 hypermorph is described. One of the new suppressor genes is bre-5, the C. elegans homolog of D. melanogaster neurogenic gene brainiac. bre-5 was previously identified in a screen for mutations that confer resistance to Bt toxin in C. elegans. BRE-5/Brainiac catalyzes a step in the synthesis of glycosphingolipids, components of lipid rafts that are thought to act as platforms for association among certain kinds of membrane-bound proteins. Reducing the activity of several other genes involved in glycosphingolipid biosynthesis also suppresses the effects of constitutive lin-12 activity. A role for glycosphingolipids as positive regulators of lin-12/Notch activity appears to be conserved, at least in invertebrates.
590 $a School code: 0054.
650 4 $a Biology, Genetics. $3 1017730
650 4 $a Biology, Molecular. $3 1017719
690 $a 0369
690 $a 0307
710 2 0 $a Columbia University. $3 571054
773 0 $t Dissertation Abstracts International $g 66-01B.
790 1 0 $a Greenwald, Iva, $e advisor
790 $a 0054
791 $a Ph.D.
792 $a 2005
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3159744