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Controlled modification of titanium ...

Danahy, Michael Peter.

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Controlled modification of titanium surfaces.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Controlled modification of titanium surfaces./
Author:	Danahy, Michael Peter.
Description:	133 p.
Notes:	Source: Dissertation Abstracts International, Volume: 65-06, Section: B, page: 2934.
Contained By:	Dissertation Abstracts International65-06B.
Subject:	Chemistry, Organic. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3135736
ISBN:	0496829513

Controlled modification of titanium surfaces.
Danahy, Michael Peter.

Controlled modification of titanium surfaces. - 133 p.

Source: Dissertation Abstracts International, Volume: 65-06, Section: B, page: 2934.

Thesis (Ph.D.)--Princeton University, 2004.

Titanium and its alloys, most notably Ti-6Al-4V, are widely used as surgical implant materials, which are in contact with bone. alpha,o-Diphosphonic acids self-assemble on the native oxide of Ti. Heating gives strongly bonded phosphate monolayers. Infrared and X-ray spectroscopic and water contact angle data show that the films are bonded to the surface by one phosphonate unit; the other remains the phosphonic acid. Surface loadings were measured by quartz crystal microbalance procedures. Mechanical shear strengths for the films were also measured; these do not correlate simply with surface loadings. Films formed from 1,12-diphosphonododecane were treated with tetra(tert -butoxy)zirconium to give surface Zr complex species; derivatives of these surface complexes are stable to hydrolysis under physiological conditions and are mechanically strong. The complexation reaction can be accomplished over the entire surface; alternatively, dropwise application of the alkoxide to the surface enables spatial control of deposition. The cell attractive peptide derivative RGDC can be bound to these surface Zr alkoxide complexes through (maleimido)alkylcarboxylate intermediates. Surfaces modified with RGDC were shown to be effective for osteoblast binding and proliferation.

ISBN: 0496829513Subjects--Topical Terms:

516206
Chemistry, Organic.

Controlled modification of titanium surfaces.
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020 $a 0496829513
035 $a (UnM)AAI3135736
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100 1 $a Danahy, Michael Peter. $3 1932741
245 1 0 $a Controlled modification of titanium surfaces.
300 $a 133 p.
500 $a Source: Dissertation Abstracts International, Volume: 65-06, Section: B, page: 2934.
500 $a Adviser: Jeffrey Schwartz.
502 $a Thesis (Ph.D.)--Princeton University, 2004.
520 $a Titanium and its alloys, most notably Ti-6Al-4V, are widely used as surgical implant materials, which are in contact with bone. alpha,o-Diphosphonic acids self-assemble on the native oxide of Ti. Heating gives strongly bonded phosphate monolayers. Infrared and X-ray spectroscopic and water contact angle data show that the films are bonded to the surface by one phosphonate unit; the other remains the phosphonic acid. Surface loadings were measured by quartz crystal microbalance procedures. Mechanical shear strengths for the films were also measured; these do not correlate simply with surface loadings. Films formed from 1,12-diphosphonododecane were treated with tetra(tert -butoxy)zirconium to give surface Zr complex species; derivatives of these surface complexes are stable to hydrolysis under physiological conditions and are mechanically strong. The complexation reaction can be accomplished over the entire surface; alternatively, dropwise application of the alkoxide to the surface enables spatial control of deposition. The cell attractive peptide derivative RGDC can be bound to these surface Zr alkoxide complexes through (maleimido)alkylcarboxylate intermediates. Surfaces modified with RGDC were shown to be effective for osteoblast binding and proliferation.
590 $a School code: 0181.
650 4 $a Chemistry, Organic. $3 516206
650 4 $a Chemistry, Inorganic. $3 517253
650 4 $a Engineering, Biomedical. $3 1017684
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690 $a 0488
690 $a 0541
710 2 0 $a Princeton University. $3 645579
773 0 $t Dissertation Abstracts International $g 65-06B.
790 1 0 $a Schwartz, Jeffrey, $e advisor
790 $a 0181
791 $a Ph.D.
792 $a 2004
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3135736