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Synthesis, characterization, and app...

Carnahan, Michael Alan.

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Synthesis, characterization, and applications of novel biodendrimers and biodendritic polymers for specific biomedical applications.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Synthesis, characterization, and applications of novel biodendrimers and biodendritic polymers for specific biomedical applications./
Author:	Carnahan, Michael Alan.
Description:	341 p.
Notes:	Source: Dissertation Abstracts International, Volume: 65-01, Section: B, page: 0241.
Contained By:	Dissertation Abstracts International65-01B.
Subject:	Chemistry, Polymer. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3120176
ISBN:	0496675486

Synthesis, characterization, and applications of novel biodendrimers and biodendritic polymers for specific biomedical applications.
Carnahan, Michael Alan.

Synthesis, characterization, and applications of novel biodendrimers and biodendritic polymers for specific biomedical applications. - 341 p.

Source: Dissertation Abstracts International, Volume: 65-01, Section: B, page: 0241.

Thesis (Ph.D.)--Duke University, 2003.

Dendrimers are monodisperse macromolecules made of branched repeat units originating from a central core. These highly branched polymers have been utilized in a variety of medical applications, but the dendritic structures have not been specifically designed for these purposes. To address this concern, novel dendrimers composed of glycerol and either lactic, succinic, or adipic acid were developed for a variety of clinically relevant applications. These "biodendrimers" are composed entirely of building blocks known to be biocompatible or degradable in vivo to natural metabolites.

ISBN: 0496675486Subjects--Topical Terms:

1018428
Chemistry, Polymer.

Synthesis, characterization, and applications of novel biodendrimers and biodendritic polymers for specific biomedical applications.
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100 1 $a Carnahan, Michael Alan. $3 1932336
245 1 0 $a Synthesis, characterization, and applications of novel biodendrimers and biodendritic polymers for specific biomedical applications.
300 $a 341 p.
500 $a Source: Dissertation Abstracts International, Volume: 65-01, Section: B, page: 0241.
500 $a Supervisor: Mark W. Grinstaff.
502 $a Thesis (Ph.D.)--Duke University, 2003.
520 $a Dendrimers are monodisperse macromolecules made of branched repeat units originating from a central core. These highly branched polymers have been utilized in a variety of medical applications, but the dendritic structures have not been specifically designed for these purposes. To address this concern, novel dendrimers composed of glycerol and either lactic, succinic, or adipic acid were developed for a variety of clinically relevant applications. These "biodendrimers" are composed entirely of building blocks known to be biocompatible or degradable in vivo to natural metabolites.
520 $a A third generation dendrimer based on glycerol and lactic acid was first synthesized through iterative esterification and deprotection reactions. Though this dendritic structure was prone to self-degradation, it led to the development of a dendrimer composed of succinic acid instead of lactic acid.
520 $a The poly(glycerol succinic acid) (PGLSA) dendrimers were prepared using a high yield divergent approach. Using a similar reaction sequence, up to five generations of the PGLSA dendrimer were synthesized and derivatized according to the desired application. Alkene terminated dendrimers were investigated as scaffolds for tissue engineering and as light activated sealants for corneal lacerations. Lysine terminated dendrimers were investigated as gene transfection agents. In addition, hydroxy- and carboxy-terminated dendrimers were used to encapsulate hydrophobic compounds.
520 $a To increase the water solubility of the dendrimers with hydrophobic peripheral functionalities, PGLSA dendrimers with a poly(ethylene glycol) core were synthesized. The methacrylated first generation of this dendrimer was used to seal 4 mm linear lacerations during in vitro studies involving human enucleated eyes and in vivo studies using the white leghorn chicken eye. These studies suggested that the use of a biodendrimer adhesive was a viable alternative clinical procedure to conventional sutures.
520 $a The PGLSA framework was also modified with a malic or adipic acid monomer to further tailor the dendritic architecture for specific applications. The adipic acid monomer lengthens the dendritic structure and may provide a larger more hydrophobic interior for the encapsulation of hydrophobic drugs. The synthesis of the layered-block dendrimers also demonstrated the reliance of the dendrimer's properties on the outer generation of monomer units.
590 $a School code: 0066.
650 4 $a Chemistry, Polymer. $3 1018428
650 4 $a Chemistry, Organic. $3 516206
650 4 $a Engineering, Biomedical. $3 1017684
690 $a 0495
690 $a 0490
690 $a 0541
710 2 0 $a Duke University. $3 569686
773 0 $t Dissertation Abstracts International $g 65-01B.
790 1 0 $a Grinstaff, Mark W., $e advisor
790 $a 0066
791 $a Ph.D.
792 $a 2003
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3120176