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The role of antibody during ovine le...

Parkyn, Geoff Robert.

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The role of antibody during ovine lentivirus disease in experimentally infected sheep.

Record Type:	Electronic resources : Monograph/item
Title/Author:	The role of antibody during ovine lentivirus disease in experimentally infected sheep./
Author:	Parkyn, Geoff Robert.
Description:	132 p.
Notes:	Source: Masters Abstracts International, Volume: 43-02, page: 0499.
Contained By:	Masters Abstracts International43-02.
Subject:	Biology, Veterinary Science. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=MQ93867
ISBN:	0612938670

The role of antibody during ovine lentivirus disease in experimentally infected sheep.
Parkyn, Geoff Robert.

The role of antibody during ovine lentivirus disease in experimentally infected sheep. - 132 p.

Source: Masters Abstracts International, Volume: 43-02, page: 0499.

Thesis (M.Sc.)--University of Prince Edward Island (Canada), 2004.

Infection of sheep by Ovine Lentivirus (OvLV) is a significant disease throughout the world, with the exception of Australia and New Zealand.

ISBN: 0612938670Subjects--Topical Terms:

1021733
Biology, Veterinary Science.

The role of antibody during ovine lentivirus disease in experimentally infected sheep.
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008 130614s2004 eng d
020 $a 0612938670
035 $a (UnM)AAIMQ93867
035 $a AAIMQ93867
040 $a UnM $c UnM
100 1 $a Parkyn, Geoff Robert. $3 1931812
245 1 4 $a The role of antibody during ovine lentivirus disease in experimentally infected sheep.
300 $a 132 p.
500 $a Source: Masters Abstracts International, Volume: 43-02, page: 0499.
500 $a Adviser: Arnost Cepica.
502 $a Thesis (M.Sc.)--University of Prince Edward Island (Canada), 2004.
520 $a Infection of sheep by Ovine Lentivirus (OvLV) is a significant disease throughout the world, with the exception of Australia and New Zealand.
520 $a In this study, the sera of four experimentally infected sheep were analysed over a two-year time period, with respect to neutralizing antibody (NT-Ab) titres and non-neutralizing ELISA antibodies against both the whole virus and the immuno-dominant recombinant proteins; capsid (CA), and trans-membrane peptide (TM). It was hypothesised that a further mechanism of persistence of OvLV may be mediated by interference of non-neutralizing antibodies with neutralizing antibody via conformational change of viral surface envelope proteins, which contain Nt-Ab epitopes. The postulated phenomenon of virus-obstructing antibody activity was investigated by analysis of correlation between neutralizing and non-neutralizing antibody responses (i.e. vs capsid/transmembrane), as well as by a neutralizing assay where high and low neutralizing antibody titre sera were analysed in a 1:1 mixture.
520 $a The report of an IgG, restricted antibody response in OvLV infection was investigated. (Abstract shortened by UMI.)
590 $a School code: 1108.
650 4 $a Biology, Veterinary Science. $3 1021733
650 4 $a Health Sciences, Immunology. $3 1017716
690 $a 0778
690 $a 0982
710 2 0 $a University of Prince Edward Island (Canada). $3 1017636
773 0 $t Masters Abstracts International $g 43-02.
790 1 0 $a Cepica, Arnost, $e advisor
790 $a 1108
791 $a M.Sc.
792 $a 2004
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=MQ93867