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Monoamine oxidase A: (1) As one of m...

Wilson, Melissa Lee.

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Monoamine oxidase A: (1) As one of many candidate genes for preeclampsia and (2) as a candidate gene for tobacco addiction.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Monoamine oxidase A: (1) As one of many candidate genes for preeclampsia and (2) as a candidate gene for tobacco addiction./
作者:	Wilson, Melissa Lee.
面頁冊數:	258 p.
附註:	Source: Dissertation Abstracts International, Volume: 65-12, Section: B, page: 6284.
Contained By:	Dissertation Abstracts International65-12B.
標題:	Biology, Genetics. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3155498
ISBN:	0496163027

Monoamine oxidase A: (1) As one of many candidate genes for preeclampsia and (2) as a candidate gene for tobacco addiction.
Wilson, Melissa Lee.

Monoamine oxidase A: (1) As one of many candidate genes for preeclampsia and (2) as a candidate gene for tobacco addiction. - 258 p.

Source: Dissertation Abstracts International, Volume: 65-12, Section: B, page: 6284.

Thesis (Ph.D.)--University of Southern California, 2004.

Monoamine oxidase A (MAO-A) is an enzyme in the mitochondrial membrane that degrades norepinephrine, serotonin, and dopamine. The gene for MAO-A is located on the X chromosome at Xp21-11. It spans 90 kb and has 15 exons and 14 introns. It is highly polymorphic with at least one functional polymorphism in the proximal promoter region, termed the upstream variable number tandem repeat (uVNTR). This repeat polymorphism consists of a 30 bp repeat reportedly present in 2, 3, 3.5, 4 or 5 copies.

ISBN: 0496163027Subjects--Topical Terms:

1017730
Biology, Genetics.

Monoamine oxidase A: (1) As one of many candidate genes for preeclampsia and (2) as a candidate gene for tobacco addiction.
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520 $a Monoamine oxidase A (MAO-A) is an enzyme in the mitochondrial membrane that degrades norepinephrine, serotonin, and dopamine. The gene for MAO-A is located on the X chromosome at Xp21-11. It spans 90 kb and has 15 exons and 14 introns. It is highly polymorphic with at least one functional polymorphism in the proximal promoter region, termed the upstream variable number tandem repeat (uVNTR). This repeat polymorphism consists of a 30 bp repeat reportedly present in 2, 3, 3.5, 4 or 5 copies.
520 $a The gene for MAO-A is a candidate gene for predisposing to preeclampsia (PE), a condition of high blood pressure and proteinuria during pregnancy which, if left untreated, can lead to maternal organ failure and preterm delivery. This dissertation contains a comprehensive review of the molecular epidemiology of PE and a grant proposal to examine the possible role of the maternal and/or fetal gene for MAO-A, genes involved in angiogenesis (VEGF, PGF, sFLT1), and a series of placentation genes (HAND1, HASH2, GCM1, HIP-1alpha, and TGFbeta3) in the development of PE.
520 $a Additionally, MAO-A has also been examined as a candidate gene for numerous mental disorders including substance abuse and addiction. To examine the possible effect of MAO-A in tobacco addiction, we conducted a nested case-control study utilizing subjects from the Singapore Chinese Health Study. We selected 490 current daily smokers smoking at least 7--12 cigarettes per day and 490 nonsmokers who reported being current daily smokers or nonsmokers at both baseline and follow-up. After excluding genotyping failures, 486 current/current smokers and 469 never/never smokers remained for analysis.
520 $a Although MAO-A genotype did not predict smoking status it did appear to influence the age at smoking initiation among the current/current smokers. Specifically, subjects with the short allele were more likely to begin smoking while still a teenager compared to subjects with the long allele (p = 0.007). There also appeared to be an increased risk of carrying the short allele for subjects who smoked more than two packs of cigarettes per day (ORunadj = 1.97, 95% CI: 0.70, 5.54), though there were not enough subjects in this category to reach statistical significance.
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