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Regulation of angiogenesis and vascu...

Grass, Taren Michelle.

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Regulation of angiogenesis and vascular remodeling by angiogenic factors.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Regulation of angiogenesis and vascular remodeling by angiogenic factors./
作者:	Grass, Taren Michelle.
面頁冊數:	92 p.
附註:	Source: Dissertation Abstracts International, Volume: 65-04, Section: B, page: 1795.
Contained By:	Dissertation Abstracts International65-04B.
標題:	Health Sciences, Pharmacology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3131100
ISBN:	0496783447

Regulation of angiogenesis and vascular remodeling by angiogenic factors.
Grass, Taren Michelle.

Regulation of angiogenesis and vascular remodeling by angiogenic factors. - 92 p.

Source: Dissertation Abstracts International, Volume: 65-04, Section: B, page: 1795.

Thesis (Ph.D.)--University of Montana, 2004.

Coronary angiogenesis is a natural response to the hypoxia associated with cardiovascular disease. Neovascularization may increase blood flow to ischemic tissue thereby improving cardiac function. However, in order for new vessel growth to become permanent and perfuse the cardiac muscle, these capillaries must mature and be stabilized by attachment of smooth muscle cells or pericytes during vascular remodeling. Therefore, a net increase in perfusion of the cardiac tissue following vascular remodeling is the essential goal of therapeutic coronary angiogenesis.

ISBN: 0496783447Subjects--Topical Terms:

1017717
Health Sciences, Pharmacology.

Regulation of angiogenesis and vascular remodeling by angiogenic factors.
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100 1 $a Grass, Taren Michelle. $3 1928683
245 1 0 $a Regulation of angiogenesis and vascular remodeling by angiogenic factors.
300 $a 92 p.
500 $a Source: Dissertation Abstracts International, Volume: 65-04, Section: B, page: 1795.
500 $a Chair: J. Douglas Coffin.
502 $a Thesis (Ph.D.)--University of Montana, 2004.
520 $a Coronary angiogenesis is a natural response to the hypoxia associated with cardiovascular disease. Neovascularization may increase blood flow to ischemic tissue thereby improving cardiac function. However, in order for new vessel growth to become permanent and perfuse the cardiac muscle, these capillaries must mature and be stabilized by attachment of smooth muscle cells or pericytes during vascular remodeling. Therefore, a net increase in perfusion of the cardiac tissue following vascular remodeling is the essential goal of therapeutic coronary angiogenesis.
520 $a Therapeutic angiogenesis strategies have primarily focused on angiogenic regulatory factors, including members of the VEGF and angiopoietin (ANG) families. However, temporal expression of these factors in relationship to the growth and remodeling phases of angiogenesis has not been established. The current study was designed to characterize the transition between angiogenesis and vascular remodeling during tissue remodeling in the ischemic murine heart and establish temporal expression patterns of ANG-1, ANG-2, Tie2 receptor, VEGF, and the phosphorylated Tie2 receptor within the context of a model of vascular growth and remodeling.
520 $a Microcauterizer-treatment of the Tie2LacZ transgenic mouse heart to generate a myocardial infarction provides a model for histologically defining angiogenic growth and remodeling. Whole mount staining of infarcted heart tissue in combination with Gomori trichrome staining, PECAM labeling, and smooth muscle alpha-actin labeling of tissue sections showed an immediate angiogenic response with a transition to vascular remodeling evident at 10d post-treatment. ANG-1, ANG-2, Tie2, and VEGF mRNA levels increased at 10d post-infarction in all targets suggesting a coordinate role for the ANG and VEGF systems in regulating the remodeling process. However, no temporal changes in protein expression were seen in ANG-1, ANG-2, Tie2, phospho-Tie2, and VEGF. In addition, immunostaining for ANG-2 demonstrated no difference in expression among the time-points. In contrast, immunostaining for phospho-Tie2 showed different patterns of expression at each of the time-points studied. The results of ANG/Tie2 and VEGF expression studies emphasize the potential complexity of determining the specific roles of these factors in the adult cardiac vasculature. Furthermore, the data suggest that future therapeutic angiogenesis strategies in the heart need to focus on both the growth and remodeling phases as critical components of effective therapies.
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710 2 0 $a University of Montana. $3 1021963
773 0 $t Dissertation Abstracts International $g 65-04B.
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790 $a 0136
791 $a Ph.D.
792 $a 2004
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