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Clinical applications of IMRT to ade...

Santanam, Lakshmi.

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Clinical applications of IMRT to adenocarcinoma of prostate: Portal dose verification and intensity modulated neutron radiotherapy.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Clinical applications of IMRT to adenocarcinoma of prostate: Portal dose verification and intensity modulated neutron radiotherapy./
Author:	Santanam, Lakshmi.
Description:	215 p.
Notes:	Source: Dissertation Abstracts International, Volume: 65-04, Section: B, page: 1938.
Contained By:	Dissertation Abstracts International65-04B.
Subject:	Physics, Radiation. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3130363
ISBN:	0496776129

Clinical applications of IMRT to adenocarcinoma of prostate: Portal dose verification and intensity modulated neutron radiotherapy.
Santanam, Lakshmi.

Clinical applications of IMRT to adenocarcinoma of prostate: Portal dose verification and intensity modulated neutron radiotherapy. - 215 p.

Source: Dissertation Abstracts International, Volume: 65-04, Section: B, page: 1938.

Thesis (Ph.D.)--Wayne State University, 2004.

Purpose. Intensity Modulated Radiotherapy (IMRT) is a modality currently being used to improve the conformality of radiotherapy dose distributions. Its application to photon radiotherapy for prostate adenocarcinoma is well established. A quality assurance tool for verifying photon IMRT treatment and the potential application of intensity modulation to neutron therapy are investigated here.

ISBN: 0496776129Subjects--Topical Terms:

1019212
Physics, Radiation.

Clinical applications of IMRT to adenocarcinoma of prostate: Portal dose verification and intensity modulated neutron radiotherapy.
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035 $a (UnM)AAI3130363
035 $a AAI3130363
040 $a UnM $c UnM
100 1 $a Santanam, Lakshmi. $3 1928678
245 1 0 $a Clinical applications of IMRT to adenocarcinoma of prostate: Portal dose verification and intensity modulated neutron radiotherapy.
300 $a 215 p.
500 $a Source: Dissertation Abstracts International, Volume: 65-04, Section: B, page: 1938.
500 $a Adviser: Jay Burmeister.
502 $a Thesis (Ph.D.)--Wayne State University, 2004.
520 $a Purpose. Intensity Modulated Radiotherapy (IMRT) is a modality currently being used to improve the conformality of radiotherapy dose distributions. Its application to photon radiotherapy for prostate adenocarcinoma is well established. A quality assurance tool for verifying photon IMRT treatment and the potential application of intensity modulation to neutron therapy are investigated here.
520 $a Materials and methods. This study evaluates the use of an amorphous silicon flat panel portal detector for dose verification of photon IMRT fields. Various correction factors were devised for an accurate estimation of dose using EPID.
520 $a For IMNRT, an in-house optimization algorithm was used for optimizing forward planned segments for the treatment of prostate cancer. For dose calculation purposes, applicability of two different dose calculation algorithms were investigated. Absolute point doses were measured at different planes in a water phantom and the results compared to that calculated by the treatment planning system. Dual ion-chamber measurements were performed to determine the neutron and the gamma doses and to estimate the whole body dose.
520 $a Results. The ratio of the dose measured with the portal imager to that measured using an ionization chamber, for 23 IMRT fields, was found to be within 0.991 +/- 0.026. The study yielded an accurate estimate of the raw difference in the relative beamlet intensity (fluence) at the plane of the detector with that of the relative intensity calculated by the planning system to within -0.65 +/- 2.69.
520 $a For IMNRT, the optimization algorithm yielded dose distributions that were superior with respect to the sparing of normal tissues. The V80 for the rectum decreased by an average of 16% for five patients planned retrospectively. For validation of the dose calculation algorithms, it was found that the beam-profiles matched to within +/-3% in the central region of the field. The small irregular fields used for IMNRT plans have been validated to an accuracy of +/-5%. Absolute dose measurements agreed with the calculated doses to within +/-3%. Whole body dose estimates for IMNRT plans generated in this study were only approximately 16% higher than conventional fast neutron therapy, and no significant variations in RBE are expected based on current measurements.
590 $a School code: 0254.
650 4 $a Physics, Radiation. $3 1019212
650 4 $a Health Sciences, Radiology. $3 1019076
690 $a 0756
690 $a 0574
710 2 0 $a Wayne State University. $3 975058
773 0 $t Dissertation Abstracts International $g 65-04B.
790 1 0 $a Burmeister, Jay, $e advisor
790 $a 0254
791 $a Ph.D.
792 $a 2004
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3130363