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Modification of polylactides for tis...

Wang, Mei.

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Modification of polylactides for tissue growth.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Modification of polylactides for tissue growth./
Author:	Wang, Mei.
Description:	86 p.
Notes:	Source: Masters Abstracts International, Volume: 42-06, page: 2213.
Contained By:	Masters Abstracts International42-06.
Subject:	Chemistry, Polymer. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1420030
ISBN:	0496247813

Modification of polylactides for tissue growth.
Wang, Mei.

Modification of polylactides for tissue growth. - 86 p.

Source: Masters Abstracts International, Volume: 42-06, page: 2213.

Thesis (M.S.)--Michigan State University, 2004.

Polylactide (PLA) and its copolymers have been used as biomedical materials due to their biocompatibility. In recent years, many studies have shown their application in tissue engineering as a biocompatible and dissolvable scaffold. Designing scaffolds that contain functionality is desirable for optimizing interaction between cell and surface. Our group has worked out chemistry to synthesize functionalizable copolymers via bulk copolymerization of L-lactide and diallylglycolide. Through hydroboration/oxidation, we successfully converted the terminal double bond to terminal hydroxyl group and by carbodiimide coupling reactions, we attached biological substrates such as fatty acids to the copolymer covalently. These uniquely modified copolymers have also been evaluated for their potential as biocompatible surfaces to direct cell growth and differentiation.

ISBN: 0496247813Subjects--Topical Terms:

1018428
Chemistry, Polymer.

Modification of polylactides for tissue growth.
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008 130614s2004 eng d
020 $a 0496247813
035 $a (UnM)AAI1420030
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040 $a UnM $c UnM
100 1 $a Wang, Mei. $3 1928313
245 1 0 $a Modification of polylactides for tissue growth.
300 $a 86 p.
500 $a Source: Masters Abstracts International, Volume: 42-06, page: 2213.
500 $a Adviser: Milton R. Smith.
502 $a Thesis (M.S.)--Michigan State University, 2004.
520 $a Polylactide (PLA) and its copolymers have been used as biomedical materials due to their biocompatibility. In recent years, many studies have shown their application in tissue engineering as a biocompatible and dissolvable scaffold. Designing scaffolds that contain functionality is desirable for optimizing interaction between cell and surface. Our group has worked out chemistry to synthesize functionalizable copolymers via bulk copolymerization of L-lactide and diallylglycolide. Through hydroboration/oxidation, we successfully converted the terminal double bond to terminal hydroxyl group and by carbodiimide coupling reactions, we attached biological substrates such as fatty acids to the copolymer covalently. These uniquely modified copolymers have also been evaluated for their potential as biocompatible surfaces to direct cell growth and differentiation.
520 $a As for tissue growth on surfaces, cell geometry has been shown to be a critical factor for death and growth. For functionalizing a biodegradable surface in a designed and well controllable fashion for further growth studies, we also worked on patterning polymer surfaces by photolabile protecting and deprotecting strategy. Anthraquinon-2-ylmethoxycarbonyl (Aqmoc) has been attached to our copolymer as the hydroxyl protecting group, and was removed by irradiating with UV light (lambda > 350nm). The synthesis and characterization of the functionalized copolymers, initial physiological experiments results are reported.
590 $a School code: 0128.
650 4 $a Chemistry, Polymer. $3 1018428
650 4 $a Engineering, Biomedical. $3 1017684
690 $a 0495
690 $a 0541
710 2 0 $a Michigan State University. $3 676168
773 0 $t Masters Abstracts International $g 42-06.
790 1 0 $a Smith, Milton R., $e advisor
790 $a 0128
791 $a M.S.
792 $a 2004
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1420030