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Modeling vascular smooth muscle cont...

Yang, Jin.

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Modeling vascular smooth muscle contraction.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Modeling vascular smooth muscle contraction./
Author:	Yang, Jin.
Description:	134 p.
Notes:	Source: Dissertation Abstracts International, Volume: 65-02, Section: B, page: 0875.
Contained By:	Dissertation Abstracts International65-02B.
Subject:	Engineering, Biomedical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3122563
ISBN:	0496699132

Modeling vascular smooth muscle contraction.
Yang, Jin.

Modeling vascular smooth muscle contraction. - 134 p.

Source: Dissertation Abstracts International, Volume: 65-02, Section: B, page: 0875.

Thesis (Ph.D.)--Rice University, 2004.

This thesis work presents a multi-scale mathematical modeling framework to investigate issues regarding vascular smooth muscle contraction. The overall structure of this thesis consists of (1) a model of single vascular smooth muscle cell membrane electrophysiology, contractile system kinetics and cell mechanics; (2) a model of signal transduction of nitric-oxide induced vascular smooth muscle relaxation, and (3) a cellular-based model for myogenic responses of isolated arteries. These models present a general and comprehensive description of VSM contraction and its associated signal transduction, which integrates information from both microscopic (cellular and subcellular interactions) and macroscopic (isolated vessel) levels. These models were utilized to investigate many underlying principles of vascular smooth muscle contraction mediated by multiple signaling pathways and can be applied to study functions of vascular smooth muscle under a variety of physiological and pathological conditions.

ISBN: 0496699132Subjects--Topical Terms:

1017684
Engineering, Biomedical.

Modeling vascular smooth muscle contraction.
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035 $a (UnM)AAI3122563
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100 1 $a Yang, Jin. $3 1926822
245 1 0 $a Modeling vascular smooth muscle contraction.
300 $a 134 p.
500 $a Source: Dissertation Abstracts International, Volume: 65-02, Section: B, page: 0875.
500 $a Chair: John W. Clark, Jr.
502 $a Thesis (Ph.D.)--Rice University, 2004.
520 $a This thesis work presents a multi-scale mathematical modeling framework to investigate issues regarding vascular smooth muscle contraction. The overall structure of this thesis consists of (1) a model of single vascular smooth muscle cell membrane electrophysiology, contractile system kinetics and cell mechanics; (2) a model of signal transduction of nitric-oxide induced vascular smooth muscle relaxation, and (3) a cellular-based model for myogenic responses of isolated arteries. These models present a general and comprehensive description of VSM contraction and its associated signal transduction, which integrates information from both microscopic (cellular and subcellular interactions) and macroscopic (isolated vessel) levels. These models were utilized to investigate many underlying principles of vascular smooth muscle contraction mediated by multiple signaling pathways and can be applied to study functions of vascular smooth muscle under a variety of physiological and pathological conditions.
590 $a School code: 0187.
650 4 $a Engineering, Biomedical. $3 1017684
650 4 $a Biophysics, Medical. $3 1017681
650 4 $a Biophysics, General. $3 1019105
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690 $a 0760
690 $a 0786
710 2 0 $a Rice University. $3 960124
773 0 $t Dissertation Abstracts International $g 65-02B.
790 1 0 $a Clark, John W., Jr., $e advisor
790 $a 0187
791 $a Ph.D.
792 $a 2004
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3122563