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The development of optical nanosenso...

Kasili, Paul Misiko.

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The development of optical nanosensor technology for single cell analysis.

Record Type:	Electronic resources : Monograph/item
Title/Author:	The development of optical nanosensor technology for single cell analysis./
Author:	Kasili, Paul Misiko.
Description:	247 p.
Notes:	Source: Dissertation Abstracts International, Volume: 65-03, Section: B, page: 1197.
Contained By:	Dissertation Abstracts International65-03B.
Subject:	Biophysics, General. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3126886
ISBN:	0496741647

The development of optical nanosensor technology for single cell analysis.
Kasili, Paul Misiko.

The development of optical nanosensor technology for single cell analysis. - 247 p.

Source: Dissertation Abstracts International, Volume: 65-03, Section: B, page: 1197.

Thesis (Ph.D.)--The University of Tennessee, 2004.

In the past decade, we have witnessed unprecedented advances in fields such as biosciences, material sciences and optical spectroscopy. Although advances in each field have provided exciting new insights and capabilities, it is the integration of these fields that revolutionary advances are being made and have been witnessed. The work presented in this dissertation is a hybrid of these fields. It describes the nanofabrication, optimization, evaluation, characterization and application of novel optical nanosensors for single cell analysis. Optical nanosensors are nanoscale size devices consisting of a transducer element and covalently immobilized biorecognition molecules. By combining the specificity of biorecognition molecules and the excellent sensitivity of laser-based optical detection, optical nanosensors are capable of detecting and differentiating biochemical constituents of complex systems enabling the provision of sensitive and specific identification of molecular events inside living cells. The capability to perform single cell analysis can dramatically improve our understanding of basic cellular processes e.g., signal transduction as well as improving our knowledge of the intracellular transport and also the fate of therapeutic agents. In addition, optical nanosensors can overcome the problem of ensemble averaging and has the potential to yield new information that is not available from population averaged cellular measurements.

ISBN: 0496741647Subjects--Topical Terms:

1019105
Biophysics, General.

The development of optical nanosensor technology for single cell analysis.
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100 1 $a Kasili, Paul Misiko. $3 1928098
245 1 4 $a The development of optical nanosensor technology for single cell analysis.
300 $a 247 p.
500 $a Source: Dissertation Abstracts International, Volume: 65-03, Section: B, page: 1197.
500 $a Major Professor: Tuan Yo-Dinh.
502 $a Thesis (Ph.D.)--The University of Tennessee, 2004.
520 $a In the past decade, we have witnessed unprecedented advances in fields such as biosciences, material sciences and optical spectroscopy. Although advances in each field have provided exciting new insights and capabilities, it is the integration of these fields that revolutionary advances are being made and have been witnessed. The work presented in this dissertation is a hybrid of these fields. It describes the nanofabrication, optimization, evaluation, characterization and application of novel optical nanosensors for single cell analysis. Optical nanosensors are nanoscale size devices consisting of a transducer element and covalently immobilized biorecognition molecules. By combining the specificity of biorecognition molecules and the excellent sensitivity of laser-based optical detection, optical nanosensors are capable of detecting and differentiating biochemical constituents of complex systems enabling the provision of sensitive and specific identification of molecular events inside living cells. The capability to perform single cell analysis can dramatically improve our understanding of basic cellular processes e.g., signal transduction as well as improving our knowledge of the intracellular transport and also the fate of therapeutic agents. In addition, optical nanosensors can overcome the problem of ensemble averaging and has the potential to yield new information that is not available from population averaged cellular measurements.
590 $a School code: 0226.
650 4 $a Biophysics, General. $3 1019105
690 $a 0786
710 2 0 $a The University of Tennessee. $3 1022026
773 0 $t Dissertation Abstracts International $g 65-03B.
790 1 0 $a Yo-Dinh, Tuan, $e advisor
790 $a 0226
791 $a Ph.D.
792 $a 2004
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3126886