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Chaos and complexity in cancer.

Al-Timimi, Ali M.

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Chaos and complexity in cancer.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Chaos and complexity in cancer./
Author:	Al-Timimi, Ali M.
Description:	116 p.
Notes:	Source: Dissertation Abstracts International, Volume: 65-10, Section: B, page: 5253.
Contained By:	Dissertation Abstracts International65-10B.
Subject:	Engineering, Biomedical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3151143
ISBN:	0496106686

Chaos and complexity in cancer.
Al-Timimi, Ali M.

Chaos and complexity in cancer. - 116 p.

Source: Dissertation Abstracts International, Volume: 65-10, Section: B, page: 5253.

Thesis (Ph.D.)--George Mason University, 2005.

It is now widely accepted that cancer is essentially a genetic disease likely caused by, or associated with, aberrant gene expression. Unlike simple genetic diseases where an inherited mutation in a single gene is sufficient to determine the pathological phenotype, cancer, among pathogenetic diseases, has the most intricate mechanism where typically numerous mutations are present. Moreover, it is understood that cancer is not a single disease but rather a group of heterogeneous diseases that share common biological properties.

ISBN: 0496106686Subjects--Topical Terms:

1017684
Engineering, Biomedical.

Chaos and complexity in cancer.
LDR:02366nmm 2200337 4500 001 1839619
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020 $a 0496106686
035 $a (UnM)AAI3151143
035 $a AAI3151143
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100 1 $a Al-Timimi, Ali M. $3 1927997
245 1 0 $a Chaos and complexity in cancer.
300 $a 116 p.
500 $a Source: Dissertation Abstracts International, Volume: 65-10, Section: B, page: 5253.
500 $a Director: D. Curtis Jamison.
502 $a Thesis (Ph.D.)--George Mason University, 2005.
520 $a It is now widely accepted that cancer is essentially a genetic disease likely caused by, or associated with, aberrant gene expression. Unlike simple genetic diseases where an inherited mutation in a single gene is sufficient to determine the pathological phenotype, cancer, among pathogenetic diseases, has the most intricate mechanism where typically numerous mutations are present. Moreover, it is understood that cancer is not a single disease but rather a group of heterogeneous diseases that share common biological properties.
520 $a Current medical theory views the pathology of cancer as an example of a complex adaptive system whose behavior expresses the interplay between order and chaos. With some cancers, tumorigenesis is driven by chaotic behavior, while other cancers show more order in their formation. Accompanying the transformation from normal to neoplastic tissue is an overall decrease in the complexity of the cell.
520 $a We have empirically investigated these notions of chaos and complexity via a study of gene expression in a wide range of normal and cancerous tissues. Our results are in fundamental agreement with what is proposed in the literature.
520 $a The significance of this type of research has been best stated as follows, "Nonlinear dynamic considerations present a new intellectual approach to cancer, which may in addition result in the development of novel therapeutic and diagnostic concepts (Sedivy 1999)."
590 $a School code: 0883.
650 4 $a Engineering, Biomedical. $3 1017684
650 4 $a Computer Science. $3 626642
650 4 $a Biology, Cell. $3 1017686
650 4 $a Health Sciences, Oncology. $3 1018566
690 $a 0541
690 $a 0984
690 $a 0379
690 $a 0992
710 2 0 $a George Mason University. $3 1019450
773 0 $t Dissertation Abstracts International $g 65-10B.
790 1 0 $a Jamison, D. Curtis, $e advisor
790 $a 0883
791 $a Ph.D.
792 $a 2005
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3151143