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Neurotrophins regulate the functions...

Zhang, Jianmin.

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Neurotrophins regulate the functions of microglia in CNS regeneration: Proliferation, survival and phagocytosis in vitro and in vivo (spinal cord).

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Neurotrophins regulate the functions of microglia in CNS regeneration: Proliferation, survival and phagocytosis in vitro and in vivo (spinal cord)./
作者:	Zhang, Jianmin.
面頁冊數:	176 p.
附註:	Source: Dissertation Abstracts International, Volume: 62-01, Section: B, page: 0103.
Contained By:	Dissertation Abstracts International62-01B.
標題:	Biology, Neuroscience. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3000482
ISBN:	0493090452

Neurotrophins regulate the functions of microglia in CNS regeneration: Proliferation, survival and phagocytosis in vitro and in vivo (spinal cord).
Zhang, Jianmin.

Neurotrophins regulate the functions of microglia in CNS regeneration: Proliferation, survival and phagocytosis in vitro and in vivo (spinal cord). - 176 p.

Source: Dissertation Abstracts International, Volume: 62-01, Section: B, page: 0103.

Thesis (Ph.D.)--University of Louisville, 2000.

Of the various types of CNS cells, the most puzzling are microglia. They are mesodermal in origin and are located in the normal adult brain in a resting stage with the ability to become mobile, active phagocytes following CNS injury. The functions of microglia following CNS injury have been greatly controversial since there is evidence which shows that microglia are both involved in neuronal regeneration and degeneration. Microglia are known to quickly respond to CNS injury by proliferating, by acting as CNS scavengers, by serving as antigen-presenting cells and by expressing a variety of growth factors and cytokines. However, the mechanisms regulating their function and activity are not fully understood. The present study employed two different types of microglial cell lines, BV-2 and N9, as well as, primary microglial cell cultures to examine the influence of members of the neurotrophin family on microglia and to characterize their effects on neurons. Furthermore, cultured microglial BV-2 cells were transplanted into injured rat spinal cord to explore the possible role of microglia in CNS regeneration following injury.

ISBN: 0493090452Subjects--Topical Terms:

1017680
Biology, Neuroscience.

Neurotrophins regulate the functions of microglia in CNS regeneration: Proliferation, survival and phagocytosis in vitro and in vivo (spinal cord).
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520 $a Of the various types of CNS cells, the most puzzling are microglia. They are mesodermal in origin and are located in the normal adult brain in a resting stage with the ability to become mobile, active phagocytes following CNS injury. The functions of microglia following CNS injury have been greatly controversial since there is evidence which shows that microglia are both involved in neuronal regeneration and degeneration. Microglia are known to quickly respond to CNS injury by proliferating, by acting as CNS scavengers, by serving as antigen-presenting cells and by expressing a variety of growth factors and cytokines. However, the mechanisms regulating their function and activity are not fully understood. The present study employed two different types of microglial cell lines, BV-2 and N9, as well as, primary microglial cell cultures to examine the influence of members of the neurotrophin family on microglia and to characterize their effects on neurons. Furthermore, cultured microglial BV-2 cells were transplanted into injured rat spinal cord to explore the possible role of microglia in CNS regeneration following injury.
520 $a Neurotrophins were demonstrated to have an influence on microglial functional activity. For example, NGF increased microglial proliferation, survival and differentiation by way of the tyrosine kinase A receptor signal transduction pathway. This growth factor also increased phagocytosis of microspheres and scar tissue from injured rat spinal cord through either opsonization or tyrosine kinase and protein kinase C pathways or both. BDNF increased microglial proliferation, survival and differentiation through the tyrosine kinase B receptor signal transduction pathway. However, BDNF was shown to decrease phagocytosis. NT-3 had no effect on microglial proliferation, survival or differentiation but had a dramatic effect on phagocytosis through the tyrosine kinase C receptor. NT-4 had no effect on cell proliferation and differentiation but had an effect on cell survival and phagocytic enhancement via the tyrosine kinase B receptor. It is possible that tyrosine kinase A is associated with cell proliferation, survival and differentiation while tyrosine kinase receptor C is associated with phagocytosis; also tyrosine kinase receptor B is associated with cross-linking of tyrosine kinase receptor A and C. (Abstract shortened by UMI.)
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