東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Novel roles for the retinal pigment ...

Cunningham, Lisa Lynn.

Linked to FindBook

Google Book

Amazon

博客來

Novel roles for the retinal pigment epithelium in expression and turnover of interphotoreceptor retinoid-binding protein.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Novel roles for the retinal pigment epithelium in expression and turnover of interphotoreceptor retinoid-binding protein./
Author:	Cunningham, Lisa Lynn.
Description:	177 p.
Notes:	Source: Dissertation Abstracts International, Volume: 60-01, Section: B, page: 0078.
Contained By:	Dissertation Abstracts International60-01B.
Subject:	Biology, Neuroscience. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9916400
ISBN:	0599151897

Novel roles for the retinal pigment epithelium in expression and turnover of interphotoreceptor retinoid-binding protein.
Cunningham, Lisa Lynn.

Novel roles for the retinal pigment epithelium in expression and turnover of interphotoreceptor retinoid-binding protein. - 177 p.

Source: Dissertation Abstracts International, Volume: 60-01, Section: B, page: 0078.

Thesis (Ph.D.)--University of Virginia, 1999.

Vertebrate visual function relies on specific interactions between the neural retina and the retinal pigment epithelium (RPE). These interactions are mediated by the interphotoreceptor matrix (IPM). The molecular components of the IPM are actively produced and secreted by the retina and RPE.

ISBN: 0599151897Subjects--Topical Terms:

1017680
Biology, Neuroscience.

Novel roles for the retinal pigment epithelium in expression and turnover of interphotoreceptor retinoid-binding protein.
LDR:02729nmm 2200301 4500 001 1839479
005 20050624104408.5
008 130614s1999 eng d
020 $a 0599151897
035 $a (UnM)AAI9916400
035 $a AAI9916400
040 $a UnM $c UnM
100 1 $a Cunningham, Lisa Lynn. $3 1927867
245 1 0 $a Novel roles for the retinal pigment epithelium in expression and turnover of interphotoreceptor retinoid-binding protein.
300 $a 177 p.
500 $a Source: Dissertation Abstracts International, Volume: 60-01, Section: B, page: 0078.
502 $a Thesis (Ph.D.)--University of Virginia, 1999.
520 $a Vertebrate visual function relies on specific interactions between the neural retina and the retinal pigment epithelium (RPE). These interactions are mediated by the interphotoreceptor matrix (IPM). The molecular components of the IPM are actively produced and secreted by the retina and RPE.
520 $a The quantities of individual IPM components are carefully regulated, and abnormal expression of matrix constituents is associated with disease. Little is known about the mechanisms regulating the amount of any matrix constituent. The major soluble protein in the IPM is interphotoreceptor retinoid-binding protein (IRBP). IRBP facilitates the exchange of retinoids during the "visual cycle".
520 $a Since IRBP is both abundant and soluble within the IPM, it provides a unique opportunity to study the mechanisms regulating turnover of matrix constituents. Regulation of IRBP removal appears to be an important determinant of its concentration in the IPM. Two systems have been used here to evaluate the expression and turnover of IRBP. Zebrafish IRBP mRNA levels are under circadian regulation. Zebrafish have herein been used to examine the relationship between this circadian mRNA expression and the amount of IRBP in the IPM. Unlike the mRNA, IRBP levels remain constant throughout the light/dark cycle, and IRBP is rapidly removed from the IPM in either light or dark.
520 $a The Xenopus laevis system has been used to examine the rate of IRBP removal from the IPM and to address potential mechanisms of IRBP turnover. IRBP is rapidly removed from the Xenopus EPM, with a biological half-life of &sim;10 hours. One potential mechanism for this rapid removal is uptake by the RPE. The RPE contains a surprisingly large proportion (20%) of the total IRBP in the eye, and uptake by the RPE occurs in conditions of either light or dark.
590 $a School code: 0246.
650 4 $a Biology, Neuroscience. $3 1017680
650 4 $a Biology, Molecular. $3 1017719
650 4 $a Biology, Animal Physiology. $3 1017835
690 $a 0317
690 $a 0307
690 $a 0433
710 2 0 $a University of Virginia. $3 645578
773 0 $t Dissertation Abstracts International $g 60-01B.
790 $a 0246
791 $a Ph.D.
792 $a 1999
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9916400