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BOVINE IMMUNOGLOBULIN ACTIVITY TO CE...

CULLOR, JAMES STERLING.

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BOVINE IMMUNOGLOBULIN ACTIVITY TO CELL WALL ANTIGENS OF A GALACTOSE 4-EPIMERASE DEFICIENT RC MUTANT OF ESCHERICHIA COLI (STRAIN J5).

Record Type:	Electronic resources : Monograph/item
Title/Author:	BOVINE IMMUNOGLOBULIN ACTIVITY TO CELL WALL ANTIGENS OF A GALACTOSE 4-EPIMERASE DEFICIENT RC MUTANT OF ESCHERICHIA COLI (STRAIN J5)./
Author:	CULLOR, JAMES STERLING.
Description:	105 p.
Notes:	Source: Dissertation Abstracts International, Volume: 47-06, Section: B, page: 2382.
Contained By:	Dissertation Abstracts International47-06B.
Subject:	Health Sciences, Pathology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=8621486

BOVINE IMMUNOGLOBULIN ACTIVITY TO CELL WALL ANTIGENS OF A GALACTOSE 4-EPIMERASE DEFICIENT RC MUTANT OF ESCHERICHIA COLI (STRAIN J5).
CULLOR, JAMES STERLING.

BOVINE IMMUNOGLOBULIN ACTIVITY TO CELL WALL ANTIGENS OF A GALACTOSE 4-EPIMERASE DEFICIENT RC MUTANT OF ESCHERICHIA COLI (STRAIN J5). - 105 p.

Source: Dissertation Abstracts International, Volume: 47-06, Section: B, page: 2382.

Thesis (Ph.D.)--University of California, Davis, 1986.

The basic principles of therapy in bacterial disease continue to be directed against the infecting organism and also the response of the host to bacterial products. Yet, gram-negative bacteremia, septicemia and the clinical manifestations of "endotoxic shock" remain difficult case management problems in veterinary medicine. The purpose of this thesis is to study a new concept in the field of immunotherapy directed towards mitigating the effects of endotoxic shock, thus reducing the severity of clinical signs and the mortality due to gram-negative disease in farm animals.Subjects--Topical Terms:

1017854
Health Sciences, Pathology.

BOVINE IMMUNOGLOBULIN ACTIVITY TO CELL WALL ANTIGENS OF A GALACTOSE 4-EPIMERASE DEFICIENT RC MUTANT OF ESCHERICHIA COLI (STRAIN J5).
LDR:02958nmm 2200277 4500 001 1839450
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008 130614s1986 d
035 $a (UnM)AAI8621486
035 $a AAI8621486
040 $a UnM $c UnM
100 1 $a CULLOR, JAMES STERLING. $3 1927840
245 1 0 $a BOVINE IMMUNOGLOBULIN ACTIVITY TO CELL WALL ANTIGENS OF A GALACTOSE 4-EPIMERASE DEFICIENT RC MUTANT OF ESCHERICHIA COLI (STRAIN J5).
300 $a 105 p.
500 $a Source: Dissertation Abstracts International, Volume: 47-06, Section: B, page: 2382.
502 $a Thesis (Ph.D.)--University of California, Davis, 1986.
520 $a The basic principles of therapy in bacterial disease continue to be directed against the infecting organism and also the response of the host to bacterial products. Yet, gram-negative bacteremia, septicemia and the clinical manifestations of "endotoxic shock" remain difficult case management problems in veterinary medicine. The purpose of this thesis is to study a new concept in the field of immunotherapy directed towards mitigating the effects of endotoxic shock, thus reducing the severity of clinical signs and the mortality due to gram-negative disease in farm animals.
520 $a The study involved (1) investigating the concept of producing antibodies to the core antigen structures presented by a galactose 4-epimerase deficient Rc mutant of Escherichia coli J5; (2) developing an assay to detect core antigen (J5) specific serum immunoglobulin G, M in both the nonimmunized and actively immunized animal; (3) to detect any protective effects of the anti-J5 antibodies in a heterologous intravenous slow infusion challenge of Salmonella typhimurium lipopolysaccharide in the bovine.
520 $a The production of antibody to gram-negative core antigen structures (anti-J5 antibody) was accomplished by active immunization with a boiled whole cell preparation. The bacterin was able to stimulate elevated anti-core antigen activity without adverse reactions (i.e. abscesses, anaphylactic shock).
520 $a A direct and indirect enzyme linked immunosorbent assay (ELISA) was developed to detect the immune response in the bovine to the whole cell E. coli J5. Increased IgM and IgG anti-J5 antibody activity could be produced; however, the use of an adjuvant enhanced this response significantly.
520 $a Endotoxic shock was induced in 5-8 week old calves by slow infusion of Salmonella typhimurium LPS over five hours. Clinical signs of endotoxic shock were less severe in the J5 immunized calves as compared to the nonimmunized controls. The results indicate a protective effect associated with IgG class antibodies directed at LPS core antigens of gram-negative bacteria during experimental endotoxic shock.
590 $a School code: 0029.
650 4 $a Health Sciences, Pathology. $3 1017854
690 $a 0571
710 2 0 $a University of California, Davis. $3 1018682
773 0 $t Dissertation Abstracts International $g 47-06B.
790 $a 0029
791 $a Ph.D.
792 $a 1986
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=8621486