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The relationship of vitamin E to cog...

Zrelak, Patricia Ann.

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The relationship of vitamin E to cognition, white matter hyperintensities and vascular risk factors in elderly Latinos.

Record Type:	Electronic resources : Monograph/item
Title/Author:	The relationship of vitamin E to cognition, white matter hyperintensities and vascular risk factors in elderly Latinos./
Author:	Zrelak, Patricia Ann.
Description:	155 p.
Notes:	Source: Dissertation Abstracts International, Volume: 64-03, Section: B, page: 1212.
Contained By:	Dissertation Abstracts International64-03B.
Subject:	Health Sciences, Public Health. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3082581
ISBN:	0496304321

The relationship of vitamin E to cognition, white matter hyperintensities and vascular risk factors in elderly Latinos.
Zrelak, Patricia Ann.

The relationship of vitamin E to cognition, white matter hyperintensities and vascular risk factors in elderly Latinos. - 155 p.

Source: Dissertation Abstracts International, Volume: 64-03, Section: B, page: 1212.

Thesis (Ph.D.)--University of California, Davis, 2003.

Higher levels of serum vitamin E are thought to be preventive in vascular disease, white matter hyperintensities, and cognitive decline. Vascular disease and dementia are thought to co-exist but the underlying pathology between the two is unknown. Mexican-Americans have been shown to have lower serum vitamin E and higher prevalence of vascular disease than non-Latino whites, but little is known about the vitamin E-vascular disease-cognitive relationship in this rapidly increasing segment of the population.

ISBN: 0496304321Subjects--Topical Terms:

1017659
Health Sciences, Public Health.

The relationship of vitamin E to cognition, white matter hyperintensities and vascular risk factors in elderly Latinos.
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020 $a 0496304321
035 $a (UnM)AAI3082581
035 $a AAI3082581
040 $a UnM $c UnM
100 1 $a Zrelak, Patricia Ann. $3 1925235
245 1 4 $a The relationship of vitamin E to cognition, white matter hyperintensities and vascular risk factors in elderly Latinos.
300 $a 155 p.
500 $a Source: Dissertation Abstracts International, Volume: 64-03, Section: B, page: 1212.
500 $a Adviser: Laurel Beckett.
502 $a Thesis (Ph.D.)--University of California, Davis, 2003.
520 $a Higher levels of serum vitamin E are thought to be preventive in vascular disease, white matter hyperintensities, and cognitive decline. Vascular disease and dementia are thought to co-exist but the underlying pathology between the two is unknown. Mexican-Americans have been shown to have lower serum vitamin E and higher prevalence of vascular disease than non-Latino whites, but little is known about the vitamin E-vascular disease-cognitive relationship in this rapidly increasing segment of the population.
520 $a The goals of this dissertation were (1) to develop and validate a tool for measuring white matter hyperintensities, (2) to investigate the cross-sectional relationship between vitamin E and cognitive functioning in a population of elderly community dwelling Latinos 60 years or older residing in the Sacramento Tri-County area, and (3) to determine whether this relationship was moderated by the presence of WMH along with an array of vascular disease risk factors.
520 $a The dissertation introduction provides an overview of the previous work in this area including the hypothesized role of oxidative stress as the unifying factor between the variables of interest. Chapter one provides a summary of the available methods for measuring white matter hyperintensities and describes: (1) the methods used to develop and validate the white matter hyperintensity scale, (2) the psychometric properties of the developed scale, and (3) the generalizability of the white matter hyperintensity results. Chapter two describes the methods used to investigate the relationship between vitamin E and cognitive functioning along with white matter hyperintensities and array of vascular risk factors in this cohort along with the study results. The conclusion provides direction for future research in this area.
520 $a Results demonstrated that subjects with decreased vitamin E had decreased cognition that remained after controlling for age, education, and smoking. This relationship was modulated by the presence of white matter hyperintensities. After accounting for white matter hyperintensities, the effects of vitamin E on cognition were decreased, suggesting that vitamin E works through the prevention of white matter hyperintensities in preventing cognitive decline. Vascular disease in general was not directly associated with cognition.
590 $a School code: 0029.
650 4 $a Health Sciences, Public Health. $3 1017659
650 4 $a Health Sciences, Nutrition. $3 1017801
650 4 $a Biology, Neuroscience. $3 1017680
650 4 $a Gerontology. $3 533633
690 $a 0573
690 $a 0570
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690 $a 0351
710 2 0 $a University of California, Davis. $3 1018682
773 0 $t Dissertation Abstracts International $g 64-03B.
790 1 0 $a Beckett, Laurel, $e advisor
790 $a 0029
791 $a Ph.D.
792 $a 2003
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3082581