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A neural model of how the cortical s...

Seitz, Aaron Robert.

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A neural model of how the cortical subplate coordinates the laminar development of orientation and ocular dominance maps.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	A neural model of how the cortical subplate coordinates the laminar development of orientation and ocular dominance maps./
作者:	Seitz, Aaron Robert.
面頁冊數:	102 p.
附註:	Source: Dissertation Abstracts International, Volume: 63-05, Section: B, page: 2237.
Contained By:	Dissertation Abstracts International63-05B.
標題:	Biology, Neuroscience. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3054532
ISBN:	0493689680

A neural model of how the cortical subplate coordinates the laminar development of orientation and ocular dominance maps.
Seitz, Aaron Robert.

A neural model of how the cortical subplate coordinates the laminar development of orientation and ocular dominance maps. - 102 p.

Source: Dissertation Abstracts International, Volume: 63-05, Section: B, page: 2237.

Thesis (Ph.D.)--Boston University, 2003.

How is development of cortical maps in V1 coordinated across cortical layers? Previous neural models propose how maps of orientation preferences (OR), ocular dominance (OD), and related properties develop in V1. These models show how spontaneous activity, before eye opening, combined with correlation learning and competition, can generate map structures similar to those found in vivo, but have not addressed laminar architecture or how cells develop their connections across cortical layers.

ISBN: 0493689680Subjects--Topical Terms:

1017680
Biology, Neuroscience.

A neural model of how the cortical subplate coordinates the laminar development of orientation and ocular dominance maps.
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245 1 2 $a A neural model of how the cortical subplate coordinates the laminar development of orientation and ocular dominance maps.
300 $a 102 p.
500 $a Source: Dissertation Abstracts International, Volume: 63-05, Section: B, page: 2237.
500 $a Major Professor: Stephen Grossberg.
502 $a Thesis (Ph.D.)--Boston University, 2003.
520 $a How is development of cortical maps in V1 coordinated across cortical layers? Previous neural models propose how maps of orientation preferences (OR), ocular dominance (OD), and related properties develop in V1. These models show how spontaneous activity, before eye opening, combined with correlation learning and competition, can generate map structures similar to those found in vivo, but have not addressed laminar architecture or how cells develop their connections across cortical layers.
520 $a This thesis suggests that the cortical subplate plays an important role in coordinating the development of cortical columns. This hypothesis is consistent with data of early cortical development. For example, afferents from the Lateral Geniculate Nucleus (LGN) "wait" in the cortical subplate for a period of weeks before growing into the cortical plate. If the subplate is ablated shortly after the LGN grows into layer 4, ocular dominance columns and orientation preferences fail to develop. Also, clusters of horizontal connections form between iso-oriented regions in layer 2/3 before they receive input from layer 4.
520 $a A new developmental neural model is proposed to describe how the cortical subplate learns a map of orientation preference and ocular dominance tuning, and teaches this map to the other cortical layers via known anatomical connections from the subplate to the cortical layers. The model accounts for the coordination of orientation and ocular dominance maps across layers, the coordination of ON and OFF subregions of simple cell receptive fields, the crude clustering of horizontal connections in layer 2/3, and the development of precise columns of coordinated receptive field properties across the multiple cortical layers. Modeling simulations emulate the order of biological development. Inputs from the LGN to the cortical subplate induce a map, which is taught to the other cortical layers. Interlaminar connections next develop, and the model is shown to be stable after subplate atrophy. Finally, patterned vision segregates ON and OFF receptive fields. Simulations also clarify how manipulating the level of neurotrophic factor BDNF, which has been shown to disrupt map formation in vivo, can influence map development by disrupting the balance of excitation and inhibition.
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