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Systems biology analysis of macropha...

Conway, James Patrick.

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Systems biology analysis of macrophage foam cells: Finding a novel function for peroxiredoxin I.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Systems biology analysis of macrophage foam cells: Finding a novel function for peroxiredoxin I./
Author:	Conway, James Patrick.
Description:	171 p.
Notes:	Source: Dissertation Abstracts International, Volume: 67-07, Section: B, page: 3540.
Contained By:	Dissertation Abstracts International67-07B.
Subject:	Biology, Cell. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3226716
ISBN:	9780542781810

Systems biology analysis of macrophage foam cells: Finding a novel function for peroxiredoxin I.
Conway, James Patrick.

Systems biology analysis of macrophage foam cells: Finding a novel function for peroxiredoxin I. - 171 p.

Source: Dissertation Abstracts International, Volume: 67-07, Section: B, page: 3540.

Thesis (Ph.D.)--Case Western Reserve University, 2007.

Atherosclerosis is a type of cardiovascular disease that is characterized by localized thickening of the arteries at sites referred to as atheromas. The earliest events leading to atheroma formation involve the oxidative modification of low-density lipoprotein in the arterial intima, and the uptake of oxidatively-modified low-density lipoprotein by intimal macrophages. This unregulated uptake results in lipid-laden macrophage-derived foam cells, which aggregate at potential sites of atheroma development known as fatty streaks.

ISBN: 9780542781810Subjects--Topical Terms:

1017686
Biology, Cell.

Systems biology analysis of macrophage foam cells: Finding a novel function for peroxiredoxin I.
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100 1 $a Conway, James Patrick. $3 1922389
245 1 0 $a Systems biology analysis of macrophage foam cells: Finding a novel function for peroxiredoxin I.
300 $a 171 p.
500 $a Source: Dissertation Abstracts International, Volume: 67-07, Section: B, page: 3540.
500 $a Adviser: Michael Kinter.
502 $a Thesis (Ph.D.)--Case Western Reserve University, 2007.
520 $a Atherosclerosis is a type of cardiovascular disease that is characterized by localized thickening of the arteries at sites referred to as atheromas. The earliest events leading to atheroma formation involve the oxidative modification of low-density lipoprotein in the arterial intima, and the uptake of oxidatively-modified low-density lipoprotein by intimal macrophages. This unregulated uptake results in lipid-laden macrophage-derived foam cells, which aggregate at potential sites of atheroma development known as fatty streaks.
520 $a We hypothesized that the transition from macrophage to foam cell is characterized by differential expression that, as a whole, is pro-atherogenic. A proteomic and transcriptomic analysis identified several proteins and mRNA transcripts that were differentially-regulated following acute and chronic exposure to oxLDL, including mediators of antioxidant and immune response. Further, chronic oxLDL exposure led to a decrease in oxLDL-induced toxicity, which coincided with an increased antioxidant response when compared to macrophages treated with a single exposure to oxLDL.
520 $a Data obtained from the analysis of differential expression in foam cells provided a foundation for the second stage of this project. Peroxiredoxin I was identified as a protein that is upregulated in macrophages following exposure to oxLDL, which led to the hypothesis that the upregulation of peroxiredoxin I could protect against toxicity induced by oxLDL-generated reactive oxygen species. It was determined that peroxiredoxin I can decrease oxLDL-induced toxicity when induced prior to oxLDL-exposure. This effect coincides with a decrease in reactive oxygen species, verifying the antioxidant role of peroxiredoxin I. Additionally, alternative functionality for peroxiredoxin I was tested, and it was determined that the activation of p38 MAPK is dependent on peroxiredoxin I expression. The sum of this data suggests that peroxiredoxin I contributes to cell survival and signaling, which affects macrophage foam cell function and survival.
590 $a School code: 0042.
650 4 $a Biology, Cell. $3 1017686
650 4 $a Biology, Bioinformatics. $3 1018415
690 $a 0379
690 $a 0715
710 2 0 $a Case Western Reserve University. $3 1017714
773 0 $t Dissertation Abstracts International $g 67-07B.
790 1 0 $a Kinter, Michael, $e advisor
790 $a 0042
791 $a Ph.D.
792 $a 2007
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3226716