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The relationship between high sensit...

Vargas, Micheline A.

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The relationship between high sensitivity C-reactive protein, metabolic syndrome and exercise.

Record Type:	Electronic resources : Monograph/item
Title/Author:	The relationship between high sensitivity C-reactive protein, metabolic syndrome and exercise./
Author:	Vargas, Micheline A.
Description:	104 p.
Notes:	Source: Dissertation Abstracts International, Volume: 67-04, Section: B, page: 1964.
Contained By:	Dissertation Abstracts International67-04B.
Subject:	Biology, Animal Physiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3214900
ISBN:	9780542663437

The relationship between high sensitivity C-reactive protein, metabolic syndrome and exercise.
Vargas, Micheline A.

The relationship between high sensitivity C-reactive protein, metabolic syndrome and exercise. - 104 p.

Source: Dissertation Abstracts International, Volume: 67-04, Section: B, page: 1964.

Thesis (Dr.P.H.)--Loma Linda University, 2006.

Purpose. The purpose of this study was to examine the relationship between hs-CRP, metabolic syndrome and physical activity. Understanding this relationship will provide insight into the potential of physical activity as a therapeutic option to reduce cardiovascular disease risk.

ISBN: 9780542663437Subjects--Topical Terms:

1017835
Biology, Animal Physiology.

The relationship between high sensitivity C-reactive protein, metabolic syndrome and exercise.
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008 130610s2006 eng d
020 $a 9780542663437
035 $a (UMI)AAI3214900
035 $a AAI3214900
040 $a UMI $c UMI
100 1 $a Vargas, Micheline A. $3 1921896
245 1 4 $a The relationship between high sensitivity C-reactive protein, metabolic syndrome and exercise.
300 $a 104 p.
500 $a Source: Dissertation Abstracts International, Volume: 67-04, Section: B, page: 1964.
500 $a Advisers: Lee S. Berk; Edward K. Fujimoto.
502 $a Thesis (Dr.P.H.)--Loma Linda University, 2006.
520 $a Purpose. The purpose of this study was to examine the relationship between hs-CRP, metabolic syndrome and physical activity. Understanding this relationship will provide insight into the potential of physical activity as a therapeutic option to reduce cardiovascular disease risk.
520 $a Methodology. This study relied on a cross-sectional, retrospective analysis of an archival database from the Center for Health Promotion (CHP). Study participants were obtained from a pool of 1,072 men and women patients at the Center of Health Promotion (CHP) at Loma Linda University. Of the 1,072 pool, 173 individuals met the inclusion criteria and were the subjects of the study. Any missing data variables were imputed using the maximum likelihood method (EM) in SYSTAT version 10; SPSS(c)2000. The distribution of hs-CRP, the dependent variable of greatest interest, was positively skewed. Therefore, a log transformation was applied to hs-CRP values for all analyses. Simple regression/correlation analysis was used to evaluate the relationships between log (CRP) and each of the relevant variables: VO2max (ml·kg -1·min-1), metabolic syndrome, and the physical activity status. The following relationships were explored: (1) hs-CRP and metabolic syndrome characteristics, (2) hs-CRP and VO2max, (3) VO2max and metabolic syndrome characteristics, and (4) VO 2max and physical activity status. Pearson Chi-square analysis was used to determine if a threshold level of physical activity was associated with hs-CRP changes.
520 $a Results. Hs-CRP increased linearly with the number of metabolic syndrome characteristics (p = 0.00022). Inverse associations were found between hs-CRP and VO2max (p = 0.00008) and between VO 2max and the number of metabolic syndrome criteria (p = 0.00004). VO 2max was positively associated with PA (p = 0.00000). Subjects engaging in 2-3 hours of PA per week had hs-CRP levels ≤ 2.5 mg/L (p = 0.01817).
520 $a Conclusions. Physical activity may reduce risk by modifying the inflammatory process. We found that hs-CRP and metabolic syndrome severity were reduced in those with a higher cardiorespiratory fitness level. These associations are suggested mechanisms by which cardiorespiratory fitness reduces the risk of CVD and diabetes. Our findings support physical activity recommendations set forth by both the Surgeon General and the American College of Sports Medicine. This study was also in support of recommendations set forth by the ATP-III report to use physical activity as first-line therapy for the management of metabolic syndrome.
520 $a Significance to preventive care. Preventive Care Specialists often prescribe physical activity as a way of reducing chronic diseases such as cardiovascular disease and diabetes. Reducing hs-CRP via regular exercise may be an intervention by which exercise reduces risk of chronic disease. This study strengths the argument that regular physical activity reduces inflammation and metabolic syndrome risk factors thereby providing protection against the number one killer in the U.S., cardiovascular disease. (Abstract shortened by UMI.)
590 $a School code: 0106.
650 4 $a Biology, Animal Physiology. $3 1017835
650 4 $a Health Sciences, Nutrition. $3 1017801
650 4 $a Health Sciences, Public Health. $3 1017659
690 $a 0433
690 $a 0570
690 $a 0573
710 2 0 $a Loma Linda University. $3 1020166
773 0 $t Dissertation Abstracts International $g 67-04B.
790 1 0 $a Berk, Lee S., $e advisor
790 1 0 $a Fujimoto, Edward K., $e advisor
790 $a 0106
791 $a Dr.P.H.
792 $a 2006
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3214900