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Functionalization of carbon nanotube...

Baker, Sarah E.

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Functionalization of carbon nanotube and nanofiber electrodes with biological macromolecules: Progress toward a nanoscale biosensor.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Functionalization of carbon nanotube and nanofiber electrodes with biological macromolecules: Progress toward a nanoscale biosensor./
Author:	Baker, Sarah E.
Description:	147 p.
Notes:	Source: Dissertation Abstracts International, Volume: 67-06, Section: B, page: 3103.
Contained By:	Dissertation Abstracts International67-06B.
Subject:	Chemistry, General. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3222841
ISBN:	9780542753367

Functionalization of carbon nanotube and nanofiber electrodes with biological macromolecules: Progress toward a nanoscale biosensor.
Baker, Sarah E.

Functionalization of carbon nanotube and nanofiber electrodes with biological macromolecules: Progress toward a nanoscale biosensor. - 147 p.

Source: Dissertation Abstracts International, Volume: 67-06, Section: B, page: 3103.

Thesis (Ph.D.)--The University of Wisconsin - Madison, 2006.

The integration of nanoscale carbon-based electrodes with biological recognition and electrical detection promises unparalleled biological detection systems. First, biologically modified carbon-based materials have been shown to have superior long-term chemical stability when compared to other commonly used materials for biological detection such as silicon, gold, and glass surfaces. Functionalizing carbon electrodes for biological recognition and using electrochemical methods to transduce biological binding information will enable real-time, hand-held, lower cost and stable biosensing devices. Nanoscale carbon-based electrodes allow the additional capability of fabricating devices with high densities of sensing elements, enabling multi-analyte detection on a single chip.

ISBN: 9780542753367Subjects--Topical Terms:

1021807
Chemistry, General.

Functionalization of carbon nanotube and nanofiber electrodes with biological macromolecules: Progress toward a nanoscale biosensor.
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100 1 $a Baker, Sarah E. $3 1921094
245 1 0 $a Functionalization of carbon nanotube and nanofiber electrodes with biological macromolecules: Progress toward a nanoscale biosensor.
300 $a 147 p.
500 $a Source: Dissertation Abstracts International, Volume: 67-06, Section: B, page: 3103.
500 $a Adviser: Robert J. Hamers.
502 $a Thesis (Ph.D.)--The University of Wisconsin - Madison, 2006.
520 $a The integration of nanoscale carbon-based electrodes with biological recognition and electrical detection promises unparalleled biological detection systems. First, biologically modified carbon-based materials have been shown to have superior long-term chemical stability when compared to other commonly used materials for biological detection such as silicon, gold, and glass surfaces. Functionalizing carbon electrodes for biological recognition and using electrochemical methods to transduce biological binding information will enable real-time, hand-held, lower cost and stable biosensing devices. Nanoscale carbon-based electrodes allow the additional capability of fabricating devices with high densities of sensing elements, enabling multi-analyte detection on a single chip.
520 $a We have worked toward the integration of these sensor components by first focusing on developing and characterizing the chemistry required to functionalize single-walled carbon nanotubes and vertically aligned carbon nanofibers with oligonucleotides and proteins for specific biological recognition. Chemical, photochemical and electrochemical methods for functionalizing these materials with biological molecules were developed. We determined, using fluorescence and colorimetric techniques, that these biologically modified nanoscale carbon electrodes are biologically active, selective, and stable.
520 $a A photochemical functionalization method enabled facile functionalization of dense arrays vertically aligned carbon nanofiber forests. We found that much of the vertically aligned carbon nanofiber sidewalls were functionalized and biologically accessible by this method---the absolute number of DNA molecules hybridized to DNA-functionalized nanofiber electrodes was &sim;8 times higher than the number of DNA molecules hybridized to flat glassy carbon electrodes and implies that nanofiber forest sensors may facilitate higher sensitivity to target DNA sequences per unit area. We also used the photochemical method for surface chemistry for linking cytochrome c to nanofiber electrodes, and the resulting immobilized protein was determined to be active and was detected electrochemically using no electrochemical mediators.
520 $a Additionally, we have developed an electrochemical functionalization method which allows for electrically-addressable biomolecular functionalization of patterned nanotubes and nanofibers. This method has enabled us to discretely functionalize individual sub-micron nanofiber regions with different DNA sequences on the same chip using no microfluidics, and will be useful for detection of multiple analytes on a single chip.
590 $a School code: 0262.
650 4 $a Chemistry, General. $3 1021807
650 4 $a Engineering, Materials Science. $3 1017759
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690 $a 0794
710 2 0 $a The University of Wisconsin - Madison. $3 626640
773 0 $t Dissertation Abstracts International $g 67-06B.
790 1 0 $a Hamers, Robert J., $e advisor
790 $a 0262
791 $a Ph.D.
792 $a 2006
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3222841