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Tumor immunolocalization using iodin...

Chaturvedi, Richa.

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Tumor immunolocalization using iodine-124 radiolabeled monoclonal antibody JAA-F11.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Tumor immunolocalization using iodine-124 radiolabeled monoclonal antibody JAA-F11./
Author:	Chaturvedi, Richa.
Description:	95 p.
Notes:	Source: Masters Abstracts International, Volume: 44-05, page: 2267.
Contained By:	Masters Abstracts International44-05.
Subject:	Health Sciences, Radiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1434232
ISBN:	9780542633058

Tumor immunolocalization using iodine-124 radiolabeled monoclonal antibody JAA-F11.
Chaturvedi, Richa.

Tumor immunolocalization using iodine-124 radiolabeled monoclonal antibody JAA-F11. - 95 p.

Source: Masters Abstracts International, Volume: 44-05, page: 2267.

Thesis (M.S.)--State University of New York at Buffalo, 2006.

Radiolabeled monoclonal antibodies (MAb) against tumor associated antigens (TAA) are used to immunolocalize occult tumors; and as scouting agents before 131I-radioimmunotherapy. Herein, 124I-JAA-F11 to Thomsen-Friedenreich antigen (TF-Ag), a carcinoma specific cell-surface TAA, is utilized in in vivo imaging experiments. Immunolocalization was performed in mice bearing the mammary adenocarcinoma metastatic line, 4T1. JAA-F11 was indirectly radioiodinated with 124I for imaging with micro-positron emission tomography (microPET) and biodistribution, which were performed at 72h, 144h, 240h, 360h, and 480h after injection and tumor tissue, blood and all organs were collected for gamma-counting. MicroPET images with high tumor-to-background contrast showed localization of the primary tumor, which remained localized until 20 days, were obtained in 100% of the mice (n=8). Biodistribution studies showed higher uptake (percentage injected dose per gram of the tissue, %ID/g) in tumors compared to other organs and blood. These results further evaluation of 131I-JAA-F11 as a radioimmunotherapy drug for clinical applications.

ISBN: 9780542633058Subjects--Topical Terms:

1019076
Health Sciences, Radiology.

Tumor immunolocalization using iodine-124 radiolabeled monoclonal antibody JAA-F11.
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