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Synthesis and application of functio...

Yang, Yue.

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Synthesis and application of functionalized diene-based polymers.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Synthesis and application of functionalized diene-based polymers./
Author:	Yang, Yue.
Description:	183 p.
Notes:	Source: Dissertation Abstracts International, Volume: 67-02, Section: B, page: 0920.
Contained By:	Dissertation Abstracts International67-02B.
Subject:	Chemistry, Polymer. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3207414
ISBN:	9780542547478

Synthesis and application of functionalized diene-based polymers.
Yang, Yue.

Synthesis and application of functionalized diene-based polymers. - 183 p.

Source: Dissertation Abstracts International, Volume: 67-02, Section: B, page: 0920.

Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2006.

A series of disubstituted functionalized dienes have been synthesized and polymerizations have been attempted. Functional groups that were incorporated into the monomers included primary amine, tertiary amine, piperidyl and methoxy groups. Among these, the dimethylamine functionalized butadienes were of the most interest and proved to have the greatest potential to be polymerized. Both free radical and anionic polymerizations have been investigated. The effect of various initiators, types of the solvent, temperature, size of the side groups and chain transfer reactions on free radical and anionic polymerizations was studied in detail. These polymers were evaluated for their potential as gene delivery vectors. Cytotoxicity, binding affinity and transfection efficiency properties were examined. A systematic study of the structure-property relationships revealed that cytotoxicity decreased as the side group of the polymers was altered. The binding affinity between the polymers and DNA also decreased as the size of the side group increased. Of the polymers studied, poly[2-(N,N-diethylaminomethyl)-1,3-butadiene], with lower cytotoxicity than poly(ethylene imine) and reasonable transfection efficiency at an N/P ratio of 2, is a promising, novel transfection vector.

ISBN: 9780542547478Subjects--Topical Terms:

1018428
Chemistry, Polymer.

Synthesis and application of functionalized diene-based polymers.
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500 $a Source: Dissertation Abstracts International, Volume: 67-02, Section: B, page: 0920.
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502 $a Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2006.
520 $a A series of disubstituted functionalized dienes have been synthesized and polymerizations have been attempted. Functional groups that were incorporated into the monomers included primary amine, tertiary amine, piperidyl and methoxy groups. Among these, the dimethylamine functionalized butadienes were of the most interest and proved to have the greatest potential to be polymerized. Both free radical and anionic polymerizations have been investigated. The effect of various initiators, types of the solvent, temperature, size of the side groups and chain transfer reactions on free radical and anionic polymerizations was studied in detail. These polymers were evaluated for their potential as gene delivery vectors. Cytotoxicity, binding affinity and transfection efficiency properties were examined. A systematic study of the structure-property relationships revealed that cytotoxicity decreased as the side group of the polymers was altered. The binding affinity between the polymers and DNA also decreased as the size of the side group increased. Of the polymers studied, poly[2-(N,N-diethylaminomethyl)-1,3-butadiene], with lower cytotoxicity than poly(ethylene imine) and reasonable transfection efficiency at an N/P ratio of 2, is a promising, novel transfection vector.
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