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Enhanced nisin production in a biofi...

Pongtharangkul, Thunyarat.

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Enhanced nisin production in a biofilm reactor and separation of nisin.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Enhanced nisin production in a biofilm reactor and separation of nisin./
Author:	Pongtharangkul, Thunyarat.
Description:	210 p.
Notes:	Source: Dissertation Abstracts International, Volume: 67-08, Section: B, page: 4240.
Contained By:	Dissertation Abstracts International67-08B.
Subject:	Biology, Microbiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3229441
ISBN:	9780542810107

Enhanced nisin production in a biofilm reactor and separation of nisin.
Pongtharangkul, Thunyarat.

Enhanced nisin production in a biofilm reactor and separation of nisin. - 210 p.

Source: Dissertation Abstracts International, Volume: 67-08, Section: B, page: 4240.

Thesis (Ph.D.)--The Pennsylvania State University, 2006.

Nisis, a 34-amino acid polypeptide produced by Lactococcus lactis subsp. lactis during the fermentation, is the only FDA approved bacteriocin for food applications. Improving nisin production through optimization of fermentation parameters would make nisin more cost-effective for various applications.

ISBN: 9780542810107Subjects--Topical Terms:

1017734
Biology, Microbiology.

Enhanced nisin production in a biofilm reactor and separation of nisin.
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100 1 $a Pongtharangkul, Thunyarat. $3 1919129
245 1 0 $a Enhanced nisin production in a biofilm reactor and separation of nisin.
300 $a 210 p.
500 $a Source: Dissertation Abstracts International, Volume: 67-08, Section: B, page: 4240.
500 $a Adviser: Ali Demirci.
502 $a Thesis (Ph.D.)--The Pennsylvania State University, 2006.
520 $a Nisis, a 34-amino acid polypeptide produced by Lactococcus lactis subsp. lactis during the fermentation, is the only FDA approved bacteriocin for food applications. Improving nisin production through optimization of fermentation parameters would make nisin more cost-effective for various applications.
520 $a In this study, a biofilm reactor with Plastic Composite Support (PCS) was evaluated for nisin production using L. lactis NIZO 22186. The high-biomass density of the biofilm reactor contributed to a significantly shorter lag time of nisin production relative to a suspended-cell reactor. The medium evaluation study suggested a complex media for nisin production in the biofilm reactor as: 4% (w/v) sucrose, 0.02% (w/v) MgSO4•7H 2O, 1% (w/v) KH2PO4, 0.2% (w/v) NaCl, 1% (w/v) peptone, and 1% (w/v) yeast extract. Nisin production in the biofilm reactor was significantly increased by 3.8-fold (2,208 IU/ml) with the suggested complex medium.
520 $a Nisin production in biofilm reactor was highly affected by the pH profiles during fermentation. In batch fermentation, profile Const4, in which pH was allowed to drop freely via autoacidification after 4 h, yielded almost 1.9-time higher nisin (3,553 IU/ml) than profile Const12 (1,898 IU/ml), possibly as a result of less adsorption of nisin onto producer cells. In fed-batch fermentation, profile Const12 enhanced nisin production in suspended-cell (4,188 IU/ml) and biofilm (4,314 IU/ml) reactors while the pH profiles that include periods of autoacidification (e.g. Const4) resulted in a significantly lower nisin production due to toxicity of lactic acid in acidic environment.
520 $a Silicic acid has been successfully used to remove nisin from the fermentation broth. The maximum recovery (47% total recovery) can be achieved when the adsorption was carried out at pH 6.8 and 1 M NaCl with 20% ethanol was used as an eluent.
520 $a Using the results from suspended-cell batch fermentation, the re-modified logistic and Gompertz models proposed in this study adequately described the growth and the validation showed that they could be used for the prediction accurately (slope = 1.01, R-square = 0.99). As for nisin production, the Luedeking-Piret model fit considerably well and could be successfully use to predict nisin production from the value of biomass (slope = 1.04, R-square = 0.98).
590 $a School code: 0176.
650 4 $a Biology, Microbiology. $3 1017734
690 $a 0410
710 2 0 $a The Pennsylvania State University. $3 699896
773 0 $t Dissertation Abstracts International $g 67-08B.
790 1 0 $a Demirci, Ali, $e advisor
790 $a 0176
791 $a Ph.D.
792 $a 2006
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3229441