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The relationship between biological ...

Jones, Tonia Lee.

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The relationship between biological and psychosocial factors, health behaviors, sociodemographic variables and immunologic response to hepatitis B vaccination in homeless adults.

Record Type:	Electronic resources : Monograph/item
Title/Author:	The relationship between biological and psychosocial factors, health behaviors, sociodemographic variables and immunologic response to hepatitis B vaccination in homeless adults./
Author:	Jones, Tonia Lee.
Description:	179 p.
Notes:	Source: Dissertation Abstracts International, Volume: 67-09, Section: B, page: 4965.
Contained By:	Dissertation Abstracts International67-09B.
Subject:	Health Sciences, Nursing. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3235749
ISBN:	9780542901614

The relationship between biological and psychosocial factors, health behaviors, sociodemographic variables and immunologic response to hepatitis B vaccination in homeless adults.
Jones, Tonia Lee.

The relationship between biological and psychosocial factors, health behaviors, sociodemographic variables and immunologic response to hepatitis B vaccination in homeless adults. - 179 p.

Source: Dissertation Abstracts International, Volume: 67-09, Section: B, page: 4965.

Thesis (Ph.D.)--University of California, Los Angeles, 2006.

Hepatitis B infection is a vaccine-preventable disease, While it is vitally important to provide preventive vaccination it is important to note that Hepatitis B vaccination responses are not predictable and may be influenced by a host of biopsychosocial factors. The purpose of this proposal was to discuss the influence of sociodemographic variables, biologic and psychologic factors, health behaviors and perceived psychological stress on hepatitis B antibody production in homeless adults. Each participant was to receive three HAV/HBV vaccines over a sixth month period from the larger study (Project Hep-Safe). Serum samples were then obtained to determine antibody response 1 month post-receipt of the second and third vaccines. The overall sample antibody response showed an expectedly wide distribution, ranging from < 5 to >1000. The mean antibody response at months three and seven were 163 and 579, respectively. The seroprotective level of the vaccine was determined to be 10 mIU or greater. The protective response rate of the vaccine for this study population at months three and seven were 41% and 88%, respectively. Biologically-related factors that affect immune response to a recombinant hepatitis B vaccine include glucose level and hepatitis C positive (HCV+) status. A relationship was found between 3 rd month antibody response and glucose levels (p=.05) and 7 th month antibody response and HCV+ status (p=.001). Individuals who self-reported a history of diabetes, also had abnormal random glucose levels. Since the age of to sample was severely skewed, a correlation between PSS and age proved unlikely (.064). Higher perceived stress scores were noted in the participants who utilized emotion-focused coping style (p=.001). Individuals who were HCV+ had a history of diabetes (p=.05) and also had higher perceived stress scores (p=.05). Sample participants who utilized emotion-focused coping style tended to report current alcohol use (p=.001). Glucose levels were also significantly correlated with emotion-focused coping style (p=.05). This study provides support for the need for a multi-factoral approach when identifying variables that may impact hepatitis B vaccination in this vulnerable, at-risk population.

ISBN: 9780542901614Subjects--Topical Terms:

1017798
Health Sciences, Nursing.

The relationship between biological and psychosocial factors, health behaviors, sociodemographic variables and immunologic response to hepatitis B vaccination in homeless adults.
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