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Recognition of the indigenous intest...

Rakoff-Nahoum, Seth.

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Recognition of the indigenous intestinal microbiota by Toll-like receptors.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Recognition of the indigenous intestinal microbiota by Toll-like receptors./
Author:	Rakoff-Nahoum, Seth.
Description:	238 p.
Notes:	Source: Dissertation Abstracts International, Volume: 67-04, Section: B, page: 1814.
Contained By:	Dissertation Abstracts International67-04B.
Subject:	Biology, Microbiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3214277
ISBN:	9780542652905

Recognition of the indigenous intestinal microbiota by Toll-like receptors.
Rakoff-Nahoum, Seth.

Recognition of the indigenous intestinal microbiota by Toll-like receptors. - 238 p.

Source: Dissertation Abstracts International, Volume: 67-04, Section: B, page: 1814.

Thesis (Ph.D.)--Yale University, 2006.

Mammals are colonized with an indigenous microbiota consisting of trillions of microorganisms. These microorganisms provide numerous benefits to host biology. Toll-like receptors (TLR) are an evolutionarily conserved family of receptors which recognize invariant structures, known as pathogen associated molecular patterns (PAMPs), present on microorganisms. TLR are critical in orchestrating both the inflammatory and adaptive arms of the immune response in protection from infection with microbial pathogens. However these effector immune responses can be deleterious to the host if unregulated. TLR cannot a priori distinguish between PAMPs derived from pathogenic or non-pathogenic microorganisms.

ISBN: 9780542652905Subjects--Topical Terms:

1017734
Biology, Microbiology.

Recognition of the indigenous intestinal microbiota by Toll-like receptors.
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008 130610s2006 eng d
020 $a 9780542652905
035 $a (UMI)AAI3214277
035 $a AAI3214277
040 $a UMI $c UMI
100 1 $a Rakoff-Nahoum, Seth. $3 1917894
245 1 0 $a Recognition of the indigenous intestinal microbiota by Toll-like receptors.
300 $a 238 p.
500 $a Source: Dissertation Abstracts International, Volume: 67-04, Section: B, page: 1814.
500 $a Adviser: Ruslan Medzhitov.
502 $a Thesis (Ph.D.)--Yale University, 2006.
520 $a Mammals are colonized with an indigenous microbiota consisting of trillions of microorganisms. These microorganisms provide numerous benefits to host biology. Toll-like receptors (TLR) are an evolutionarily conserved family of receptors which recognize invariant structures, known as pathogen associated molecular patterns (PAMPs), present on microorganisms. TLR are critical in orchestrating both the inflammatory and adaptive arms of the immune response in protection from infection with microbial pathogens. However these effector immune responses can be deleterious to the host if unregulated. TLR cannot a priori distinguish between PAMPs derived from pathogenic or non-pathogenic microorganisms.
520 $a The goal of this dissertation has been to determine how deleterious responses to the indigenous microbiota are avoided and to understand the role of TLRs in the recognition of the commensal microflora.
520 $a The experiments described herein reveal an unexpected beneficial role of commensal-TLR interactions in intestinal homeostasis and protection from injury. Relatedly, TLRs also appear to be important positive regulators of intestinal tumorigenesis. The study of two models of commensal-dependent, spontaneous colitis has revealed that immune intestinal homeostasis is maintained by non-redundant regulation of recognition of the indigenous microbiota involving both TLR-dependent and TLR-independent pathways.
590 $a School code: 0265.
650 4 $a Biology, Microbiology. $3 1017734
650 4 $a Biology, Animal Physiology. $3 1017835
650 4 $a Health Sciences, Immunology. $3 1017716
690 $a 0410
690 $a 0433
690 $a 0982
710 2 0 $a Yale University. $3 515640
773 0 $t Dissertation Abstracts International $g 67-04B.
790 1 0 $a Medzhitov, Ruslan, $e advisor
790 $a 0265
791 $a Ph.D.
792 $a 2006
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3214277