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Developmental expression of Drosophi...

Concel, Vincent Jonathan.

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Developmental expression of Drosophila RNP-4F, a fly homologue of the human P110/Sart3 protein and U4/U6 snRNP recycling factor.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Developmental expression of Drosophila RNP-4F, a fly homologue of the human P110/Sart3 protein and U4/U6 snRNP recycling factor./
作者:	Concel, Vincent Jonathan.
面頁冊數:	76 p.
附註:	Source: Masters Abstracts International, Volume: 43-04, page: 1199.
Contained By:	Masters Abstracts International43-04.
標題:	Biology, Genetics. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1424761
ISBN:	9780496919680

Developmental expression of Drosophila RNP-4F, a fly homologue of the human P110/Sart3 protein and U4/U6 snRNP recycling factor.
Concel, Vincent Jonathan.

Developmental expression of Drosophila RNP-4F, a fly homologue of the human P110/Sart3 protein and U4/U6 snRNP recycling factor. - 76 p.

Source: Masters Abstracts International, Volume: 43-04, page: 1199.

Thesis (M.S.)--Case Western Reserve University (Health Sciences), 2005.

Drosophila rnp-4f is a single-copy gene which was the first reported example of a gene in Drosophila to display RNA editing of its transcripts. It is predicted that RNP-4F proteins 943 and 639 amino acids long arise from two non-edited cDNAs that undergo alternative splicing. These isoforms exhibit &sim;22% sequence identity and &sim;40% sequence similarity to other family members. The 943aa RNP-4F protein has one RRM, 3 HAT domains common to known RNA binding proteins, and the 12aa highly conserved LSM motif at the extreme C-terminus. Drosophila RNP-4F is a homologue of human P110/Sart3 and Prp24 which function as U4/U6 di-snRNP recycling factors. The exact function of RNP-4F is unknown but may play a role in RNA splicing in Drosophila. Western blot analysis reveals a complex temporal pattern of RNP-4F proteins developmentally regulated. Consistent with RNA localization data, immunostaining shows a uniform distribution of RNP-4F in most cells and tissues.

ISBN: 9780496919680Subjects--Topical Terms:

1017730
Biology, Genetics.

Developmental expression of Drosophila RNP-4F, a fly homologue of the human P110/Sart3 protein and U4/U6 snRNP recycling factor.
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245 1 0 $a Developmental expression of Drosophila RNP-4F, a fly homologue of the human P110/Sart3 protein and U4/U6 snRNP recycling factor.
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520 $a Drosophila rnp-4f is a single-copy gene which was the first reported example of a gene in Drosophila to display RNA editing of its transcripts. It is predicted that RNP-4F proteins 943 and 639 amino acids long arise from two non-edited cDNAs that undergo alternative splicing. These isoforms exhibit &sim;22% sequence identity and &sim;40% sequence similarity to other family members. The 943aa RNP-4F protein has one RRM, 3 HAT domains common to known RNA binding proteins, and the 12aa highly conserved LSM motif at the extreme C-terminus. Drosophila RNP-4F is a homologue of human P110/Sart3 and Prp24 which function as U4/U6 di-snRNP recycling factors. The exact function of RNP-4F is unknown but may play a role in RNA splicing in Drosophila. Western blot analysis reveals a complex temporal pattern of RNP-4F proteins developmentally regulated. Consistent with RNA localization data, immunostaining shows a uniform distribution of RNP-4F in most cells and tissues.
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