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Corneal mean curvature mapping: Appl...

Tang, Maolong.

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Corneal mean curvature mapping: Applications in laser refractive surgery.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Corneal mean curvature mapping: Applications in laser refractive surgery./
作者:	Tang, Maolong.
面頁冊數:	110 p.
附註:	Source: Dissertation Abstracts International, Volume: 65-07, Section: B, page: 3571.
Contained By:	Dissertation Abstracts International65-07B.
標題:	Engineering, Biomedical. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3141759
ISBN:	9780496888399

Corneal mean curvature mapping: Applications in laser refractive surgery.
Tang, Maolong.

Corneal mean curvature mapping: Applications in laser refractive surgery. - 110 p.

Source: Dissertation Abstracts International, Volume: 65-07, Section: B, page: 3571.

Thesis (Ph.D.)--The Ohio State University, 2004.

Every year, there are millions of people going through corneal refractive surgery. Laser in-situ keratomileusis (LASIK) is the most commonly performed procedure. Although most LASIK patients found the visual outcome satisfactory, LASIK is not perfect in all respects.

ISBN: 9780496888399Subjects--Topical Terms:

1017684
Engineering, Biomedical.

Corneal mean curvature mapping: Applications in laser refractive surgery.
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500 $a Source: Dissertation Abstracts International, Volume: 65-07, Section: B, page: 3571.
500 $a Advisers: David Huang; Cynthia Roberts.
502 $a Thesis (Ph.D.)--The Ohio State University, 2004.
520 $a Every year, there are millions of people going through corneal refractive surgery. Laser in-situ keratomileusis (LASIK) is the most commonly performed procedure. Although most LASIK patients found the visual outcome satisfactory, LASIK is not perfect in all respects.
520 $a One area that needs improvement is pre-surgical screening for keratoconus. Pre-surgical screening for keratoconus is important because even mild cases of keratoconus can lead to severe keratectasia after LASIK. However, identifying mild cases of keratoconus is still a challenge using current diagnostic approaches like corneal topography. In the late models of corneal topography systems, many new representations and index systems were introduced to improve the visualization of subtle abnormalities in the anterior corneal shape. In this study, we exploited one of the modern representations of corneal topography, called mean curvature mapping, as a more sensitive method to detect subtle shape abnormalities. We found that mean curvature mapping may be a better way to quantify the parameters of keratoconus such as location of cone peak, cone magnitude, and cone diameter.
520 $a Another area that needs improvement in laser refractive surgery is reduction of surgically-induced corneal aberrations, which may lead to uneven quality of visual in dim light and glare. Post-surgical epithelial remodeling plays a very important role in the unexpected difference between the actual and intended results of laser ablation, which eventually leads to post-surgical corneal aberrations. In this study, we devised a mathematical model of epithelial remodeling based on an epithelial transport theory. This model predicts that the epithelial thickness is modulated by corneal surface mean curvature and this produces a surface smoothing effect which occurs after LASIK. Our model treats corneal epithelial smoothing as linear shift-invariant operation with one major parameter: smoothing constant. Based on the refractive outcome of LASIK series, we found the smoothing constant to be approximately 0.5mm. The model agrees quantitatively with observed epithelial thickening in the center of a myopic ablation zone and in the periphery of a hyperopic ablation zone. The model also successfully predicts the induction of positive spherical aberration after myopic ablation and negative spherical aberration after hyperopic correction.
520 $a The mathematical model was used as the basis to design ablation patterns that compensate in advance for the expected corneal surface smoothing response. To my knowledge, this model is the first quantitative theory that allows us to provide a general approach to ablation design. Theoretically, this ablation algorithm can be programmed to pre-compensate for all orders of surgically-induced aberrations due to corneal epithelial healing. By compensating for the expected epithelial healing, this ablation pattern can decrease post-surgical aberrations which could potentially improve the quality of vision. We called this the "Advanced Healing-Adjusted Ablation" (AHAA) algorithm.
590 $a School code: 0168.
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