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The effects of opioid receptor antag...

Hikoi, Hirotaka.

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The effects of opioid receptor antagonism on plasma catecholamines and fat metabolism during prolonged exercise above or below lactate threshold in males.

Record Type:	Electronic resources : Monograph/item
Title/Author:	The effects of opioid receptor antagonism on plasma catecholamines and fat metabolism during prolonged exercise above or below lactate threshold in males./
Author:	Hikoi, Hirotaka.
Description:	150 p.
Notes:	Source: Dissertation Abstracts International, Volume: 60-06, Section: B, page: 2444.
Contained By:	Dissertation Abstracts International60-06B.
Subject:	Biology, Animal Physiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9933190
ISBN:	9780599337497

The effects of opioid receptor antagonism on plasma catecholamines and fat metabolism during prolonged exercise above or below lactate threshold in males.
Hikoi, Hirotaka.

The effects of opioid receptor antagonism on plasma catecholamines and fat metabolism during prolonged exercise above or below lactate threshold in males. - 150 p.

Source: Dissertation Abstracts International, Volume: 60-06, Section: B, page: 2444.

Thesis (Ph.D.)--Oregon State University, 1999.

The present study investigated the effects of an opioid antagonist, naloxone (NAL), on plasma concentrations of catecholamines (norepinephrine and epinephrine), glycerol, and free fatty acids (FFA) and fatty acid and carbohydrate oxidation (indirect calorimetry) during exercise at an intensity above or below lactate threshold (LT) in 20 trained males (age, 24.1 +/- 4.4 yr; VO2peak , 62.7 +/- 6.0 ml·kg-1·min -1). The subjects were randomly assigned to one of two groups performing 30-minute cycling at an intensity either 10% above or below their individual LT. Each subject in each group performed two exercise tests in separate occasions with an injection of either NAL (1.2 mg) or saline placebo (PLC) in a double-blind, counterbalanced order. NAL or PLC was injected through a Teflon catheter located in a radial vein 15 minutes before exercise. Plasma levels of norepinephrine increased during exercise above and below LT and were significantly higher above LT than below LT (p < 0.05). NAL administration did not significantly alter plasma levels of catecholamines during exercise either above or below LT. Plasma levels of glycerol and FFA during exercise did not differ between the two intensities. NAL failed to produce significant changes in plasma glycerol or FFA either above or below LT. Fatty acid oxidation during exercise was identical between the two intensities, whereas carbohydrate oxidation was significantly higher above LT than below LT (p < 0.05). NAL did not significantly influence fatty acid and carbohydrate oxidation during exercise either above or below LT. In conclusion, during exercise at an intensity 10% above or 10% below LT, endogenous opioid may not play regulatory roles in catecholamine secretion and substrate metabolism. Enhanced carbohydrate oxidation contributed to elevated energy demands during exercise above LT.

ISBN: 9780599337497Subjects--Topical Terms:

1017835
Biology, Animal Physiology.

The effects of opioid receptor antagonism on plasma catecholamines and fat metabolism during prolonged exercise above or below lactate threshold in males.
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100 1 $a Hikoi, Hirotaka. $3 1914053
245 1 4 $a The effects of opioid receptor antagonism on plasma catecholamines and fat metabolism during prolonged exercise above or below lactate threshold in males.
300 $a 150 p.
500 $a Source: Dissertation Abstracts International, Volume: 60-06, Section: B, page: 2444.
500 $a Adviser: Anthony R. Wilcox.
502 $a Thesis (Ph.D.)--Oregon State University, 1999.
520 $a The present study investigated the effects of an opioid antagonist, naloxone (NAL), on plasma concentrations of catecholamines (norepinephrine and epinephrine), glycerol, and free fatty acids (FFA) and fatty acid and carbohydrate oxidation (indirect calorimetry) during exercise at an intensity above or below lactate threshold (LT) in 20 trained males (age, 24.1 +/- 4.4 yr; VO2peak , 62.7 +/- 6.0 ml·kg-1·min -1). The subjects were randomly assigned to one of two groups performing 30-minute cycling at an intensity either 10% above or below their individual LT. Each subject in each group performed two exercise tests in separate occasions with an injection of either NAL (1.2 mg) or saline placebo (PLC) in a double-blind, counterbalanced order. NAL or PLC was injected through a Teflon catheter located in a radial vein 15 minutes before exercise. Plasma levels of norepinephrine increased during exercise above and below LT and were significantly higher above LT than below LT (p < 0.05). NAL administration did not significantly alter plasma levels of catecholamines during exercise either above or below LT. Plasma levels of glycerol and FFA during exercise did not differ between the two intensities. NAL failed to produce significant changes in plasma glycerol or FFA either above or below LT. Fatty acid oxidation during exercise was identical between the two intensities, whereas carbohydrate oxidation was significantly higher above LT than below LT (p < 0.05). NAL did not significantly influence fatty acid and carbohydrate oxidation during exercise either above or below LT. In conclusion, during exercise at an intensity 10% above or 10% below LT, endogenous opioid may not play regulatory roles in catecholamine secretion and substrate metabolism. Enhanced carbohydrate oxidation contributed to elevated energy demands during exercise above LT.
590 $a School code: 0172.
650 4 $a Biology, Animal Physiology. $3 1017835
650 4 $a Health Sciences, Nutrition. $3 1017801
650 4 $a Health Sciences, Recreation. $3 1018003
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710 2 0 $a Oregon State University. $3 625720
773 0 $t Dissertation Abstracts International $g 60-06B.
790 1 0 $a Wilcox, Anthony R., $e advisor
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791 $a Ph.D.
792 $a 1999
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9933190