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Induction of the acute phase respons...

Verdun, Mark.

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Induction of the acute phase response by long-term aerobic exercise.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Induction of the acute phase response by long-term aerobic exercise./
Author:	Verdun, Mark.
Description:	297 p.
Notes:	Source: Dissertation Abstracts International, Volume: 60-03, Section: B, page: 0909.
Contained By:	Dissertation Abstracts International60-03B.
Subject:	Biology, Animal Physiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9923677
ISBN:	9780599231931

Induction of the acute phase response by long-term aerobic exercise.
Verdun, Mark.

Induction of the acute phase response by long-term aerobic exercise. - 297 p.

Source: Dissertation Abstracts International, Volume: 60-03, Section: B, page: 0909.

Thesis (Ph.D.)--Ohio University, 1999.

This experiment investigated whether an acute phase response (APR) to long-term aerobic exercise could be induced and manipulated by metabolic means without muscle damage. A simultaneous increase in plasma IL-6, serum cortisol, and serum CRP was interpreted as evidence of an APR.

ISBN: 9780599231931Subjects--Topical Terms:

1017835
Biology, Animal Physiology.

Induction of the acute phase response by long-term aerobic exercise.
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100 1 $a Verdun, Mark. $3 1914040
245 1 0 $a Induction of the acute phase response by long-term aerobic exercise.
300 $a 297 p.
500 $a Source: Dissertation Abstracts International, Volume: 60-03, Section: B, page: 0909.
500 $a Director: Anne B. Loucks.
502 $a Thesis (Ph.D.)--Ohio University, 1999.
520 $a This experiment investigated whether an acute phase response (APR) to long-term aerobic exercise could be induced and manipulated by metabolic means without muscle damage. A simultaneous increase in plasma IL-6, serum cortisol, and serum CRP was interpreted as evidence of an APR.
520 $a Nine healthy, non-obese, sedentary males (mean +/- SE, 20 +/- 0.4 yrs, 14 +/- 1.1% body fat, 68 +/- 2.2 kg LBM, 49.9 +/- 0.09 ml/kg/min VO2max) completed one resting treatment and four exercise treatments in which they walked uphill on a treadmill while consuming either an aspartame-sweetened placebo solution (PLC) or a 10% dextrose solution (DEX) until they expended 30 kcal/kgLBM of energy at both 50% (PLC50 and DEX50) or 70% (PLC70 and DEX70) VO2max. During DEX treatments, subjects consumed 30 kcal/kgLBM of energy (DEX50: 29.5 +/- 0.1 kcal/kgLBM and DEX70: 29.1 +/- 0.1 kcal/kgLBM) to replace the energy expended during exercise.
520 $a Rises in serum CK did not exceed 150 U/L for any subject during any treatment, indicating that negligible muscle damage occurred. At both PLC exercise intensities, the plasma IL-6, serum cortisol and serum CRP all rose (PLC50, all p < 0.003 and PLC70, all p < 0.001), indicating the occurrence of an APR. Plasma norepinephrine (NE) (PLC50, p < 0.001 and PLC70, p < 0.001) and total WBC count (PLC50, p = 0.001 and PLC70, p < 0.001) also increased.
520 $a Dextrose administration had no effect on plasma NE (50% VO2max: p = 0.20; 70% VO2max: p = 0.17), but it did blunt the exercise-induced APR at both 50% (all p < 0.004) and 70% (all p < 0.005) VO2max, as well as the rise in total WBC count at both 50% (p = 0.03) and 70% (p = 0.02) VO2max.
520 $a Lowering exercise intensity from 70% to 50% VO2max reduced plasma NE (PLC, p = 0.005 and DEX, p = 0.02) and the total WBC count (PLC, p = 0.05 and DEX, p = 0.02), but it did not blunt the exercise-induced APR during either PLC or DEX treatments. The effectiveness of DEX in suppressing the APR, plasma NE, and total WBC count were not dependent on exercise intensity.
520 $a Thus, long-term aerobic exercise that does not cause muscle damage is capable of inducing an APR that is, at least in part, driven by the metabolic demands of exercise, independent of exercise intensity.
590 $a School code: 0167.
650 4 $a Biology, Animal Physiology. $3 1017835
650 4 $a Health Sciences, Recreation. $3 1018003
690 $a 0433
690 $a 0575
710 2 0 $a Ohio University. $3 626637
773 0 $t Dissertation Abstracts International $g 60-03B.
790 1 0 $a Loucks, Anne B., $e advisor
790 $a 0167
791 $a Ph.D.
792 $a 1999
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9923677