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Biodegradable poly(3-hydroxyalkanoat...

He, Jidong.

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Biodegradable poly(3-hydroxyalkanoate)s and fullerene-derived drugs.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Biodegradable poly(3-hydroxyalkanoate)s and fullerene-derived drugs./
作者:	He, Jidong.
面頁冊數:	106 p.
附註:	Source: Dissertation Abstracts International, Volume: 66-11, Section: B, page: 5918.
Contained By:	Dissertation Abstracts International66-11B.
標題:	Health Sciences, Pharmacology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3195399
ISBN:	9780542402517

Biodegradable poly(3-hydroxyalkanoate)s and fullerene-derived drugs.
He, Jidong.

Biodegradable poly(3-hydroxyalkanoate)s and fullerene-derived drugs. - 106 p.

Source: Dissertation Abstracts International, Volume: 66-11, Section: B, page: 5918.

Thesis (Ph.D.)--Hong Kong Polytechnic University (People's Republic of China), 2005.

The major objectives of this dissertation are to assess the structure-properties relationships of (1) polyhydroxyalkanoates (PHAs), and of (2) a new water-soluble [60]fullerol synthesized by me that has potential as a therapeutic agent.

ISBN: 9780542402517Subjects--Topical Terms:

1017717
Health Sciences, Pharmacology.

Biodegradable poly(3-hydroxyalkanoate)s and fullerene-derived drugs.
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245 1 0 $a Biodegradable poly(3-hydroxyalkanoate)s and fullerene-derived drugs.
300 $a 106 p.
500 $a Source: Dissertation Abstracts International, Volume: 66-11, Section: B, page: 5918.
500 $a Adviser: Man Ken Cheung.
502 $a Thesis (Ph.D.)--Hong Kong Polytechnic University (People's Republic of China), 2005.
520 $a The major objectives of this dissertation are to assess the structure-properties relationships of (1) polyhydroxyalkanoates (PHAs), and of (2) a new water-soluble [60]fullerol synthesized by me that has potential as a therapeutic agent.
520 $a PHAs are biodegradable polyesters that can be synthesized from renewable sources by numerous bacteria. There is considerable potential for the design of PHAs for applications in drug delivery. PHB, P(HB-HV), and P(HB-HHx) are the most commonly found members of the PHA family. PHB has a narrow thermal processing window. However, the properties of P(HB-HV) and P(HB-HHx) vary widely depending on the mole percentage of HV and HHx in the copolymers. So it is important to determine the thermal properties in order to improve the thermal processing of these biopolymers.
520 $a Water-soluble C60 derivatives can interact with DNA, proteins and living cells. Due to their photochemistry and radical quenching, multiple hydroxyl water-soluble fullerol will have broad clinical applications including drug synthesis.
520 $a In the first part of the experiment, thermal analyses of PHB, P(HB-HV), and P(HB-HHx) were conducted with thermogravimetry (TG) and differential scanning calorimetry (DSC). The experimental results show that the incorporation of 30 mol 3-hydroxyvalerate (HV) and 15 mol % 3-hydroxyhexanoate (HHx) components into the polyester increased the various thermal degradation relative to those of PHB by 3-12°C (measured at B = 40°C min-1). DSC measurements showed that the incorporation of HV and HHx decreased the melting temperature relative to that of PHB by 70°C.
520 $a In the second part of the experiment, the thermal degradation kinetics of PHB and P(HB-HV) under nitrogen was studied by TG. The thermal degradation mechanism of PHB and P(HB-HV) under nitrogen was investigated with TG-FTIR and Py-GC/MS. The results show that the degradation products of PHB are mainly propene, 2-butenoic acid, propenyl-2-butenoate and butyric-2-butenoate, whereas, those of P(HB-HV) are mainly propene, 2-butenoic acid, 2-pentenoic acid, propenyl-2-butenoate, propenyl-2-pentenoate, butyric-2-butenoate, pentanoic-2-pentenoate and CO 2. The degradation is probably initiated from the chain scission of the ester linkage.
520 $a In the third part, the experiment focused on the synthesis and characterization of water-soluble ethoxy [60]fullerol. A novel fullerene derivative C 60(OCH2CH3)8(OH)16 was synthesized through the substitution of bromine atoms from C60Br24 in CH3CH2OH/H2O/NaOH solution at ambient temperature (23°C). Both the results of IR and NMR determination showed that the hydoxyl groups and ethoxy groups were bonded to the [60]fullerene cage. The antioxidant activity of ethoxy [60]fullerol is very weak. Ethoxy [60]fullerol has antitumor activity.
590 $a School code: 1170.
650 4 $a Health Sciences, Pharmacology. $3 1017717
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710 2 0 $a Hong Kong Polytechnic University (People's Republic of China). $3 1288341
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790 $a 1170
791 $a Ph.D.
792 $a 2005
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