東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Quantitative imaging techniques for ...

Pollard, Rachel Elizabeth.

FindBook

Google Book

Amazon

博客來

Quantitative imaging techniques for the assessment of tumor microvasculature.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Quantitative imaging techniques for the assessment of tumor microvasculature./
作者:	Pollard, Rachel Elizabeth.
面頁冊數:	154 p.
附註:	Source: Dissertation Abstracts International, Volume: 66-04, Section: B, page: 2026.
Contained By:	Dissertation Abstracts International66-04B.
標題:	Health Sciences, Radiology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3171901
ISBN:	9780542085901

Quantitative imaging techniques for the assessment of tumor microvasculature.
Pollard, Rachel Elizabeth.

Quantitative imaging techniques for the assessment of tumor microvasculature. - 154 p.

Source: Dissertation Abstracts International, Volume: 66-04, Section: B, page: 2026.

Thesis (Ph.D.)--University of California, Davis, 2005.

Vascular endothelial growth factor (VEGF) and its receptors VEGF-receptor 1 (VEGF-R1) and VEGF-receptor 2 (VEGF-R2) have been shown to play a major role in tumor angiogenesis. A number of conventional therapeutic agents and gene therapy strategies have been employed as specific inhibitors of VEGF and have been proposed as potential anti-tumoral, anti-angiogenesis agents. Because of these recently developed strategies for inhibiting tumor growth and metastasis through microvascular growth suppression, repetitive, non-invasive imaging of tumor angiogenesis and microvascular blood flow has become an important investigational tool for evaluating the effects of angiogenesis suppressing agents. Contrast enhanced computed tomography is currently used to identify and define the morphology of tumors. Likewise, ultrasound has been used for many years to diagnose and characterize parenchymal lesions such as solid tumors. There are currently a number of stabilized microbubble preparations either actively on the market or in late phase clinical trials that, when injected intravascularly, serve as ultrasound contrast enhancement agents. Using a novel combination of pulse sequences estimates of regional flow velocity and quantitative estimates of blood flow can be made. The purpose of this series of studies was to use new methods of both dynamic contrast enhanced computed tomography and contrast enhanced ultrasound to develop non-invasive methods for quantifying and serially monitoring tumor blood flow and permeability. These methods of evaluation were used to repeatedly monitor tumors during uninhibited growth and during anti-angiogenesis therapy. Both dynamic contrast enhanced computed tomography and ultrasound were able to provide anatomic and functional information regarding tumor microcirculation. Measures made with these novel imaging strategies correlated with gold standard techniques. The results of this series of studies will act as a cornerstone for future studies directed at characterizing tumors by their microcirculation, permeability and flow characteristics, and in repetitive assessment of tumor response to anti-angiogenesis agents.

ISBN: 9780542085901Subjects--Topical Terms:

1019076
Health Sciences, Radiology.

Quantitative imaging techniques for the assessment of tumor microvasculature.
LDR:03087nmm 2200289 4500 001 1824193
005 20061128083228.5
008 130610s2005 eng d
020 $a 9780542085901
035 $a (UnM)AAI3171901
035 $a AAI3171901
040 $a UnM $c UnM
100 1 $a Pollard, Rachel Elizabeth. $3 1913281
245 1 0 $a Quantitative imaging techniques for the assessment of tumor microvasculature.
300 $a 154 p.
500 $a Source: Dissertation Abstracts International, Volume: 66-04, Section: B, page: 2026.
500 $a Adviser: Erik R. Wisner.
502 $a Thesis (Ph.D.)--University of California, Davis, 2005.
520 $a Vascular endothelial growth factor (VEGF) and its receptors VEGF-receptor 1 (VEGF-R1) and VEGF-receptor 2 (VEGF-R2) have been shown to play a major role in tumor angiogenesis. A number of conventional therapeutic agents and gene therapy strategies have been employed as specific inhibitors of VEGF and have been proposed as potential anti-tumoral, anti-angiogenesis agents. Because of these recently developed strategies for inhibiting tumor growth and metastasis through microvascular growth suppression, repetitive, non-invasive imaging of tumor angiogenesis and microvascular blood flow has become an important investigational tool for evaluating the effects of angiogenesis suppressing agents. Contrast enhanced computed tomography is currently used to identify and define the morphology of tumors. Likewise, ultrasound has been used for many years to diagnose and characterize parenchymal lesions such as solid tumors. There are currently a number of stabilized microbubble preparations either actively on the market or in late phase clinical trials that, when injected intravascularly, serve as ultrasound contrast enhancement agents. Using a novel combination of pulse sequences estimates of regional flow velocity and quantitative estimates of blood flow can be made. The purpose of this series of studies was to use new methods of both dynamic contrast enhanced computed tomography and contrast enhanced ultrasound to develop non-invasive methods for quantifying and serially monitoring tumor blood flow and permeability. These methods of evaluation were used to repeatedly monitor tumors during uninhibited growth and during anti-angiogenesis therapy. Both dynamic contrast enhanced computed tomography and ultrasound were able to provide anatomic and functional information regarding tumor microcirculation. Measures made with these novel imaging strategies correlated with gold standard techniques. The results of this series of studies will act as a cornerstone for future studies directed at characterizing tumors by their microcirculation, permeability and flow characteristics, and in repetitive assessment of tumor response to anti-angiogenesis agents.
590 $a School code: 0029.
650 4 $a Health Sciences, Radiology. $3 1019076
650 4 $a Health Sciences, Oncology. $3 1018566
650 4 $a Engineering, Biomedical. $3 1017684
690 $a 0574
690 $a 0992
690 $a 0541
710 2 0 $a University of California, Davis. $3 1018682
773 0 $t Dissertation Abstracts International $g 66-04B.
790 1 0 $a Wisner, Erik R., $e advisor
790 $a 0029
791 $a Ph.D.
792 $a 2005
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3171901