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Possible interactions between phosph...

Macias, Sandra G.

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Possible interactions between phospholipase A(2)S and COX-2 in colon carcinoma cell line, HT-29.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Possible interactions between phospholipase A(2)S and COX-2 in colon carcinoma cell line, HT-29./
Author:	Macias, Sandra G.
Description:	73 p.
Notes:	Source: Masters Abstracts International, Volume: 44-03, page: 1274.
Contained By:	Masters Abstracts International44-03.
Subject:	Biology, Cell. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1430241
ISBN:	9780542404627

Possible interactions between phospholipase A(2)S and COX-2 in colon carcinoma cell line, HT-29.
Macias, Sandra G.

Possible interactions between phospholipase A(2)S and COX-2 in colon carcinoma cell line, HT-29. - 73 p.

Source: Masters Abstracts International, Volume: 44-03, page: 1274.

Thesis (M.S.)--The University of Texas at El Paso, 2005.

Hyper-arachidonic acid metabolism in colonic epithelial carcinoma cells has been linked to the increased production of inflammatory agents that promote tumorigenesis, angiogenesis, and other hallmarks of cancer cells. Although both secretory phospholipase-A2 (sPLA2) and cytoplasmic phospholipase-A2 (cPLA2) were shown to be involved in releasing arachidonic acid (AA) from arachidonoyl-phospholipads (AA-PL) during malignancy, nothing is known regarding their interplay at the cellular level. Through microarray and quantitative RT-PCR analyses, it has been shown that short-term (4 hours) administration of AA (25 muM/106 cells) in HT-29 cells results in upregulation of a multitude of genes including Ca2+ dependent PLA2 (cPLA2), secretory PLA2 (sPLA2), several oncogenes and protein kinases. The inhibition of sPLA2 activity by aristolochic acid (ArA, 160 muM/10 6 cells) reduces the expression of cPLA2, Rab 7 and Jun messages but increases COX-2 transcription. (Abstract shortened by UMI.)

ISBN: 9780542404627Subjects--Topical Terms:

1017686
Biology, Cell.

Possible interactions between phospholipase A(2)S and COX-2 in colon carcinoma cell line, HT-29.
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035 $a (UnM)AAI1430241
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100 1 $a Macias, Sandra G. $3 1913260
245 1 0 $a Possible interactions between phospholipase A(2)S and COX-2 in colon carcinoma cell line, HT-29.
300 $a 73 p.
500 $a Source: Masters Abstracts International, Volume: 44-03, page: 1274.
500 $a Adviser: Sid Das.
502 $a Thesis (M.S.)--The University of Texas at El Paso, 2005.
520 $a Hyper-arachidonic acid metabolism in colonic epithelial carcinoma cells has been linked to the increased production of inflammatory agents that promote tumorigenesis, angiogenesis, and other hallmarks of cancer cells. Although both secretory phospholipase-A2 (sPLA2) and cytoplasmic phospholipase-A2 (cPLA2) were shown to be involved in releasing arachidonic acid (AA) from arachidonoyl-phospholipads (AA-PL) during malignancy, nothing is known regarding their interplay at the cellular level. Through microarray and quantitative RT-PCR analyses, it has been shown that short-term (4 hours) administration of AA (25 muM/106 cells) in HT-29 cells results in upregulation of a multitude of genes including Ca2+ dependent PLA2 (cPLA2), secretory PLA2 (sPLA2), several oncogenes and protein kinases. The inhibition of sPLA2 activity by aristolochic acid (ArA, 160 muM/10 6 cells) reduces the expression of cPLA2, Rab 7 and Jun messages but increases COX-2 transcription. (Abstract shortened by UMI.)
590 $a School code: 0459.
650 4 $a Biology, Cell. $3 1017686
650 4 $a Health Sciences, Oncology. $3 1018566
690 $a 0379
690 $a 0992
710 2 0 $a The University of Texas at El Paso. $3 1057446
773 0 $t Masters Abstracts International $g 44-03.
790 1 0 $a Das, Sid, $e advisor
790 $a 0459
791 $a M.S.
792 $a 2005
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1430241