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Neurogenesis of adult stem cells fro...

Deng, Jie.

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Neurogenesis of adult stem cells from the liver and bone marrow.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Neurogenesis of adult stem cells from the liver and bone marrow./
Author:	Deng, Jie.
Description:	143 p.
Notes:	Source: Dissertation Abstracts International, Volume: 66-06, Section: B, page: 2906.
Contained By:	Dissertation Abstracts International66-06B.
Subject:	Biology, Cell. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3177959
ISBN:	9780542177842

Neurogenesis of adult stem cells from the liver and bone marrow.
Deng, Jie.

Neurogenesis of adult stem cells from the liver and bone marrow. - 143 p.

Source: Dissertation Abstracts International, Volume: 66-06, Section: B, page: 2906.

Thesis (Ph.D.)--University of Florida, 2005.

Recent reports of the adult stem cell multipotencies have generated tremendous interest regarding their potential therapeutic value, while bypassing ethical concerns surrounding the use of human embryonic stem cells. Among the different adult stem cells, the bone marrow-derived mesenchymal stem cells (MSCs) may represent the best hope for cell replacement therapy since, in addition to their multipotency and accessibility, MSCs may also be used in autologous transplantations to minimize immune rejection. The isolation of a large number of hepatic oval cells (HOCs) holds tremendous promise as a source for liver transplantation in treating both acute and chronic liver failure. With the recent reports of the traps-differentiation of oval cells into the insulin-producing pancreatic cells, as well as neural-like cells in vivo, using HOCs in treating diseased tissues other than liver may also be possible.

ISBN: 9780542177842Subjects--Topical Terms:

1017686
Biology, Cell.

Neurogenesis of adult stem cells from the liver and bone marrow.
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100 1 $a Deng, Jie. $3 1913158
245 1 0 $a Neurogenesis of adult stem cells from the liver and bone marrow.
300 $a 143 p.
500 $a Source: Dissertation Abstracts International, Volume: 66-06, Section: B, page: 2906.
500 $a Chairman: Bryon E. Petersen.
502 $a Thesis (Ph.D.)--University of Florida, 2005.
520 $a Recent reports of the adult stem cell multipotencies have generated tremendous interest regarding their potential therapeutic value, while bypassing ethical concerns surrounding the use of human embryonic stem cells. Among the different adult stem cells, the bone marrow-derived mesenchymal stem cells (MSCs) may represent the best hope for cell replacement therapy since, in addition to their multipotency and accessibility, MSCs may also be used in autologous transplantations to minimize immune rejection. The isolation of a large number of hepatic oval cells (HOCs) holds tremendous promise as a source for liver transplantation in treating both acute and chronic liver failure. With the recent reports of the traps-differentiation of oval cells into the insulin-producing pancreatic cells, as well as neural-like cells in vivo, using HOCs in treating diseased tissues other than liver may also be possible.
520 $a The use of stem cell therapy in treating neurodegenerative disorders has attracted considerable attention lately. In Parkinson's disease (PD), the engraftment of fetal mesencephalic neurons, which are rich in postmitotic dopaminergic neurons, has significantly improved the patient symptoms. But limited by ethical issues as well as short of supplies in utilizing embryonic tissue, the alternative to use adult stem cells has moved to the forefront of the research. The trans-differentiation of MSCs into neural cell types has been explored extensively, with several groups reporting that these stem cells can traps-differentiate into neurons, astrocytes and microglias. However, controversies of the adult stem cell multipotency arose after reports of failures to repeat several significant previous experiments, as well as confounding factors of possible cell contamination or fusion.
520 $a In an attempt to clarify these issues, I studied two types of adult stem cells, the mesenchymal bone marrow derived cells (BMDCs) and the hepatic oval cells. There is a significant difference between these two types of adult stem cell in their capability to differentiate into neural phenotypes. While the BMDCs spontaneously generate neurogenic and astrogenic progenitors, HOCs showed little sign of neural trans-differentiation capability in vitro . However, both BMDCs and HOCs differentiated and expressed neural specific proteins after they were grafted into the neurogenic subependymal zone of the neonatal mouse brains.
590 $a School code: 0070.
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650 4 $a Biology, Neuroscience. $3 1017680
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710 2 0 $a University of Florida. $3 718949
773 0 $t Dissertation Abstracts International $g 66-06B.
790 1 0 $a Petersen, Bryon E., $e advisor
790 $a 0070
791 $a Ph.D.
792 $a 2005
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3177959