東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Fluconazole resistance in Candida kr...

Scott, LaKeshia.

Linked to FindBook

Google Book

Amazon

博客來

Fluconazole resistance in Candida krusei.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Fluconazole resistance in Candida krusei./
Author:	Scott, LaKeshia.
Description:	43 p.
Notes:	Source: Masters Abstracts International, Volume: 43-05, page: 1669.
Contained By:	Masters Abstracts International43-05.
Subject:	Biology, Molecular. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1430851
ISBN:	9780542017087

Fluconazole resistance in Candida krusei.
Scott, LaKeshia.

Fluconazole resistance in Candida krusei. - 43 p.

Source: Masters Abstracts International, Volume: 43-05, page: 1669.

Thesis (M.S.)--California State University, Dominguez Hills, 2005.

Fluconazole is an antifungal agent used to treat fungal infections. Candida krusei---inherently resistant to fluconazole---is of concern due to its emergence as an invasive infectious agent. Resistance to fluconazole in C. krusei is associated with reduced susceptibility of the enzyme cytochrome P450 sterol 14alpha-demethylase (CYP51) to inhibition by the antifungal agent.

ISBN: 9780542017087Subjects--Topical Terms:

1017719
Biology, Molecular.

Fluconazole resistance in Candida krusei.
LDR:01966nmm 2200301 4500 001 1823982
005 20061128084451.5
008 130610s2005 eng d
020 $a 9780542017087
035 $a (UnM)AAI1430851
035 $a AAI1430851
040 $a UnM $c UnM
100 1 $a Scott, LaKeshia. $3 1913075
245 1 0 $a Fluconazole resistance in Candida krusei.
300 $a 43 p.
500 $a Source: Masters Abstracts International, Volume: 43-05, page: 1669.
500 $a Adviser: Scott Filler.
502 $a Thesis (M.S.)--California State University, Dominguez Hills, 2005.
520 $a Fluconazole is an antifungal agent used to treat fungal infections. Candida krusei---inherently resistant to fluconazole---is of concern due to its emergence as an invasive infectious agent. Resistance to fluconazole in C. krusei is associated with reduced susceptibility of the enzyme cytochrome P450 sterol 14alpha-demethylase (CYP51) to inhibition by the antifungal agent.
520 $a We compared the amino acid sequence of C. krusei CYP51 (ckCYP51) to fluconazole-susceptible strain of Candida albicans (caCYP51). Site-directed mutagenesis used changed amino acids differences between the sensitive caCYP51 and resistant ckCYP51. The fluconazole susceptibility of S. cerevisiae expressing these candidal CYP51s was determined by measuring the minimum inhibitory concentration (MIC).
520 $a Yeast expressing wild type ckCYP51 had fluconazole MIC, 256mug/ml, whereas caCYP51 was 32mug/ml. MIC for yeast expressing the mutant ckCYP51 containing amino acid substitutions L113F, W145K, S315A, and T512V was 256mug/ml. These amino acid substitutions did not increase susceptibility of C. krusei to fluconazole.
590 $a School code: 0582.
650 4 $a Biology, Molecular. $3 1017719
650 4 $a Biology, Microbiology. $3 1017734
690 $a 0307
690 $a 0410
710 2 0 $a California State University, Dominguez Hills. $3 1017917
773 0 $t Masters Abstracts International $g 43-05.
790 1 0 $a Filler, Scott, $e advisor
790 $a 0582
791 $a M.S.
792 $a 2005
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1430851