語系:
繁體中文
English
說明(常見問題)
回圖書館首頁
手機版館藏查詢
登入
回首頁
切換:
標籤
|
MARC模式
|
ISBD
Primary and secondary CD8+ T cell re...
~
Lindell, Dennis Michael.
FindBook
Google Book
Amazon
博客來
Primary and secondary CD8+ T cell responses to pulmonary fungal infection.
紀錄類型:
書目-電子資源 : Monograph/item
正題名/作者:
Primary and secondary CD8+ T cell responses to pulmonary fungal infection./
作者:
Lindell, Dennis Michael.
面頁冊數:
189 p.
附註:
Source: Dissertation Abstracts International, Volume: 66-02, Section: B, page: 0798.
Contained By:
Dissertation Abstracts International66-02B.
標題:
Health Sciences, Immunology. -
電子資源:
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3163872
ISBN:
9780496984251
Primary and secondary CD8+ T cell responses to pulmonary fungal infection.
Lindell, Dennis Michael.
Primary and secondary CD8+ T cell responses to pulmonary fungal infection.
- 189 p.
Source: Dissertation Abstracts International, Volume: 66-02, Section: B, page: 0798.
Thesis (Ph.D.)--University of Michigan, 2005.
The objective of this thesis was to define the role of CD8+ T cells in the pulmonary immune response to the fungal pathogen, Cryptococcus neoformans. In humans, C. neoformans infection is common, but severe disease primarily affects individuals with compromised CD4+ T cell function. Using a established mouse model of pulmonary C. neoformans infection, we studied CD8 + T cell responses to C. neoformans in immunocompetent (CD4+ T cell sufficient) and CD4+ T cell deficient hosts. In immunocompetent mice, CD8+ T cells proliferated in secondary lymphoid tissues, but did not become activated, or acquire effector function until reaching the site of primary infection, where CD8+ T cells in the lungs produced the macrophage activating cytokine IFNgamma. When re-stimulated with a variety of C. neoformans antigens, CD4+ and CD8+ T cells from secondary lymphoid tissues of infected mice proliferated whereas lung T cell produced effector cytokines. These results demonstrated compartmentalized function of CD8 + T cells during pulmonary C. neoformans infection.
ISBN: 9780496984251Subjects--Topical Terms:
1017716
Health Sciences, Immunology.
Primary and secondary CD8+ T cell responses to pulmonary fungal infection.
LDR
:03391nmm 2200313 4500
001
1823873
005
20061128084403.5
008
130610s2005 eng d
020
$a
9780496984251
035
$a
(UnM)AAI3163872
035
$a
AAI3163872
040
$a
UnM
$c
UnM
100
1
$a
Lindell, Dennis Michael.
$3
1912968
245
1 0
$a
Primary and secondary CD8+ T cell responses to pulmonary fungal infection.
300
$a
189 p.
500
$a
Source: Dissertation Abstracts International, Volume: 66-02, Section: B, page: 0798.
500
$a
Chair: Gary B. Huffnagle.
502
$a
Thesis (Ph.D.)--University of Michigan, 2005.
520
$a
The objective of this thesis was to define the role of CD8+ T cells in the pulmonary immune response to the fungal pathogen, Cryptococcus neoformans. In humans, C. neoformans infection is common, but severe disease primarily affects individuals with compromised CD4+ T cell function. Using a established mouse model of pulmonary C. neoformans infection, we studied CD8 + T cell responses to C. neoformans in immunocompetent (CD4+ T cell sufficient) and CD4+ T cell deficient hosts. In immunocompetent mice, CD8+ T cells proliferated in secondary lymphoid tissues, but did not become activated, or acquire effector function until reaching the site of primary infection, where CD8+ T cells in the lungs produced the macrophage activating cytokine IFNgamma. When re-stimulated with a variety of C. neoformans antigens, CD4+ and CD8+ T cells from secondary lymphoid tissues of infected mice proliferated whereas lung T cell produced effector cytokines. These results demonstrated compartmentalized function of CD8 + T cells during pulmonary C. neoformans infection.
520
$a
In many circumstances, CD4+ T cell deficiency results in an impaired CD8+ T cell response. The CD8+ T cell response to C. neoformans was not dependent on CD4 + T cells, and instead CD4+ T cell deficiency resulted in an exaggerated CD8+ T cell response. CD8+ T cells became activated, trafficked to the lungs, and produced IFNgamma in the absence of CD4+ T cells. During CD4+ T cell deficiency, CD8+ T cells provided a level of protection against C. neoformans, promoting monocyte/macrophage recruitment to the lungs, and limiting intracellular infection of macrophages. However, CD8+ T cells alone were not sufficient for resolution of C. neoformans infection.
520
$a
Immunocompetent mice which had resolved primary C. neoformans infection controlled a secondary fungal challenge more rapidly, even in the presence of low-level persistent primary infection. The secondary immune response was characterized by: (1) higher frequencies of IFNgamma production by CD8+ T cells; (2) higher numbers of responding CD8+ T cells; (3) faster resolution of microbial infection; (4) faster resolution of pulmonary inflammation. Cumulatively, these results demonstrate that CD8+ T cells play a complementary role to CD4+ T cells in protective cell-mediated immunity to C. neoformans. During CD4+ T cell deficiency, however, CD8+ T cells play a critical role in limiting pulmonary C. neoformans infection.
590
$a
School code: 0127.
650
4
$a
Health Sciences, Immunology.
$3
1017716
650
4
$a
Biology, Microbiology.
$3
1017734
650
4
$a
Health Sciences, Medicine and Surgery.
$3
1017756
690
$a
0982
690
$a
0410
690
$a
0564
710
2 0
$a
University of Michigan.
$3
777416
773
0
$t
Dissertation Abstracts International
$g
66-02B.
790
1 0
$a
Huffnagle, Gary B.,
$e
advisor
790
$a
0127
791
$a
Ph.D.
792
$a
2005
856
4 0
$u
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3163872
筆 0 讀者評論
館藏地:
全部
電子資源
出版年:
卷號:
館藏
1 筆 • 頁數 1 •
1
條碼號
典藏地名稱
館藏流通類別
資料類型
索書號
使用類型
借閱狀態
預約狀態
備註欄
附件
W9214736
電子資源
11.線上閱覽_V
電子書
EB
一般使用(Normal)
在架
0
1 筆 • 頁數 1 •
1
多媒體
評論
新增評論
分享你的心得
Export
取書館
處理中
...
變更密碼
登入