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The role of D1 and D2 dopamine recep...

Choi, Won Yung.

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The role of D1 and D2 dopamine receptors in the expression of a simple appetitive response at different stages of learning.

Record Type:	Electronic resources : Monograph/item
Title/Author:	The role of D1 and D2 dopamine receptors in the expression of a simple appetitive response at different stages of learning./
Author:	Choi, Won Yung.
Description:	144 p.
Notes:	Source: Dissertation Abstracts International, Volume: 66-09, Section: B, page: 5074.
Contained By:	Dissertation Abstracts International66-09B.
Subject:	Psychology, Behavioral. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3188728
ISBN:	9780542315305

The role of D1 and D2 dopamine receptors in the expression of a simple appetitive response at different stages of learning.
Choi, Won Yung.

The role of D1 and D2 dopamine receptors in the expression of a simple appetitive response at different stages of learning. - 144 p.

Source: Dissertation Abstracts International, Volume: 66-09, Section: B, page: 5074.

Thesis (Ph.D.)--Columbia University, 2005.

In this paper, the role of dopamine in unconditioned and conditioned behavioral responses at different stages of learning was critically examined. Rats were trained to respond to an auditory cue by executing a head entry response into a food compartment to retrieve a food reward. In Study 1, vulnerability of the response to D1 receptor blockade was examined at different stages of learning. During early stages of training, D1 receptor blockade impaired the expression of both cued head entry responses and uncued checking of pellets in the trough during the intertrial interval (ITI). In contrast, after extended training, only the uncued ITI head entry responses were impaired with a D1 antagonist, indicating that overtraining reduces D1 receptor mediation of the expression of a cued response for an appetitive stimulus. In Study 2, differential effects of D1 and D2 dopamine receptor blockade on the expression of cued and uncued head entry responses were examined during an early stage of learning. D1 receptor blockade reduced the frequency of uncued ITI head entry responses and increased the latency of cued responses whereas D2 receptor blockade increased the duration of both cued and uncued head entry responses. This suggests that the initiation of a simple approach response is mediated by D1 but not D2 receptors, while the termination of the same response is mediated by D2 but not D1 receptors. In Study 3, targeted central infusion of a D1 antagonist into the nucleus accumbens core (NAcc), the dorsomedial striatum, and the medial prefrontal cortex produced locomotor suppression. Reductions in the frequency of uncued head entries were produced by infusion of the D1 antagonist into the NAcc and the dorsomedial striatum, suggesting that these regions play a role in the performance of this approach behavior. No single infusion disrupted newly-learned cued responses. These results reveal functional dissociations in the role of D1 receptors within its various forebrain target sites in the performance of locomotion and an appetitive approach response.

ISBN: 9780542315305Subjects--Topical Terms:

1017677
Psychology, Behavioral.

The role of D1 and D2 dopamine receptors in the expression of a simple appetitive response at different stages of learning.
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520 $a In this paper, the role of dopamine in unconditioned and conditioned behavioral responses at different stages of learning was critically examined. Rats were trained to respond to an auditory cue by executing a head entry response into a food compartment to retrieve a food reward. In Study 1, vulnerability of the response to D1 receptor blockade was examined at different stages of learning. During early stages of training, D1 receptor blockade impaired the expression of both cued head entry responses and uncued checking of pellets in the trough during the intertrial interval (ITI). In contrast, after extended training, only the uncued ITI head entry responses were impaired with a D1 antagonist, indicating that overtraining reduces D1 receptor mediation of the expression of a cued response for an appetitive stimulus. In Study 2, differential effects of D1 and D2 dopamine receptor blockade on the expression of cued and uncued head entry responses were examined during an early stage of learning. D1 receptor blockade reduced the frequency of uncued ITI head entry responses and increased the latency of cued responses whereas D2 receptor blockade increased the duration of both cued and uncued head entry responses. This suggests that the initiation of a simple approach response is mediated by D1 but not D2 receptors, while the termination of the same response is mediated by D2 but not D1 receptors. In Study 3, targeted central infusion of a D1 antagonist into the nucleus accumbens core (NAcc), the dorsomedial striatum, and the medial prefrontal cortex produced locomotor suppression. Reductions in the frequency of uncued head entries were produced by infusion of the D1 antagonist into the NAcc and the dorsomedial striatum, suggesting that these regions play a role in the performance of this approach behavior. No single infusion disrupted newly-learned cued responses. These results reveal functional dissociations in the role of D1 receptors within its various forebrain target sites in the performance of locomotion and an appetitive approach response.
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