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Dog leukocyte antigen (DLA) class II...

Angles, John Malcolm.

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Dog leukocyte antigen (DLA) class II diversity in the domestic purebred dog.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Dog leukocyte antigen (DLA) class II diversity in the domestic purebred dog./
作者:	Angles, John Malcolm.
面頁冊數:	214 p.
附註:	Source: Dissertation Abstracts International, Volume: 66-04, Section: B, page: 1932.
Contained By:	Dissertation Abstracts International66-04B.
標題:	Biology, Veterinary Science. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3171861
ISBN:	9780542085185

Dog leukocyte antigen (DLA) class II diversity in the domestic purebred dog.
Angles, John Malcolm.

Dog leukocyte antigen (DLA) class II diversity in the domestic purebred dog. - 214 p.

Source: Dissertation Abstracts International, Volume: 66-04, Section: B, page: 1932.

Thesis (Ph.D.)--University of California, Davis, 2005.

The popularity of the purebred domestic dog is rapidly increasing. Given the great differences in human likes and dislikes, it is not surprising that more than 400 breeds of domestic dog exist. Breed standards, considered by some as 'breed barriers', have been imposed by specific registries to maintain these traits. These standards have led to an amazing degree of compartmentalization of genetic diversity within each breed. The aim of the present study was to determine if breed standards result in low DLA class II allele and haplotype diversity in the purebred dog. Further, if this restriction in haplotype diversity was noted, was it possible to differentiate breeds of dog. Twenty-five American Kennel Club (AKC) registered breeds (at least 10 unrelated animals per breed) were typed for dog leukocyte antigen (DLA) class II DRB1, DQA1 and DQB1. Reduced diversity at each of the DLA class II genes was evident within each of these breeds, with high levels of homozygosity present for some breeds. It was possible to differentiate most breeds based on allele and haplotype information for these class II genes. Some alleles and haplotypes were common across all breeds, while others were breed-specific. It can be concluded that DLA class II typing supports two conclusions: (1) each pure breed of dogs reflects its own peculiar phenotypic selection pressure, and this selection is manifested in a narrowing of DLA class II gene diversity and breed specific haplotyping, and (2) a sharing of certain DLA class II gene alleles and haplotypes across breeds indicates that the founders of modern breeds were derived from a common founder population. The American Akita dog exhibits high levels of autoimmune disease, and was selected for further evaluation for DLA associations. Uveodermatological syndrome (UV) of the American Akita is similar to the human leukocyte antigen (HLA) associated disease Vogt-Koyanagi-Harada (VKH) syndrome. DLA-DQA1*00201 was found to be significantly increased (RR = 15.4) in UV-affected American Akita dogs compared to normal American Akita dogs. These studies confirm breed restriction of DLA class II diversity, and suggest that the purebred dog will be a good model for autoimmune disease investigation.

ISBN: 9780542085185Subjects--Topical Terms:

1021733
Biology, Veterinary Science.

Dog leukocyte antigen (DLA) class II diversity in the domestic purebred dog.
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