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The synthesis, characterization and ...

Li, Qiang.

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The synthesis, characterization and biomedical applications of photocrosslinkable polymers.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	The synthesis, characterization and biomedical applications of photocrosslinkable polymers./
作者:	Li, Qiang.
面頁冊數:	243 p.
附註:	Source: Dissertation Abstracts International, Volume: 66-04, Section: B, page: 2180.
Contained By:	Dissertation Abstracts International66-04B.
標題:	Engineering, Biomedical. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3172637
ISBN:	9780542102691

The synthesis, characterization and biomedical applications of photocrosslinkable polymers.
Li, Qiang.

The synthesis, characterization and biomedical applications of photocrosslinkable polymers. - 243 p.

Source: Dissertation Abstracts International, Volume: 66-04, Section: B, page: 2180.

Thesis (Ph.D.)--The Johns Hopkins University, 2005.

The studies on tissue engineering and drug/protein controlled release have gained tremendous advancements in the last a couple of decades. The synthesis and application of new biomaterials with desirable physicochemical properties and biological functions as tissue engineering scaffolds or as drug/protein controlled release carriers are under extensive research and exploration. In particular, hydrogel, which possesses good biocompatibility, certain mechanical strength and allows the free transport of nutrients and waste, shows great application potential in biomaterials field. Our group is interested in the photopolymerization technique for the formation of hydrogel because the whole process is minimally invasive and fast and the spatial and temporal control can be easily achieved by confining the light source.

ISBN: 9780542102691Subjects--Topical Terms:

1017684
Engineering, Biomedical.

The synthesis, characterization and biomedical applications of photocrosslinkable polymers.
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245 1 4 $a The synthesis, characterization and biomedical applications of photocrosslinkable polymers.
300 $a 243 p.
500 $a Source: Dissertation Abstracts International, Volume: 66-04, Section: B, page: 2180.
500 $a Adviser: Jennifer H. Elisseeff.
502 $a Thesis (Ph.D.)--The Johns Hopkins University, 2005.
520 $a The studies on tissue engineering and drug/protein controlled release have gained tremendous advancements in the last a couple of decades. The synthesis and application of new biomaterials with desirable physicochemical properties and biological functions as tissue engineering scaffolds or as drug/protein controlled release carriers are under extensive research and exploration. In particular, hydrogel, which possesses good biocompatibility, certain mechanical strength and allows the free transport of nutrients and waste, shows great application potential in biomaterials field. Our group is interested in the photopolymerization technique for the formation of hydrogel because the whole process is minimally invasive and fast and the spatial and temporal control can be easily achieved by confining the light source.
520 $a The first polymer series PPE-HA-ACRL was synthesized based on the polyphosphoester (PPE) with adjustable chemical structure. The hydrogel blocks with different crosslinking densities were obtained through photocrosslinking. The swelling behaviors, degradation profile, mechanical properties and biocompatibility of PPE-HA-ACRL were then characterized. Using carbonyldiimidazole (CDI) as the crosslinker, PPE-HA-ACRL macromer was grafted onto the surface of hydroxyapatite (HA) particles and finally the modified HA particles (HA-PA) were able to be successfully immobilized into the hydrogel scaffolds with even distribution through the photocrosslinking. The 2-D cell seeding experiments showed improved the cell attachment and metabolic activity when the hydrogel discs were incorporated with HA-PA. Finally the human osteoblasts (hFOB) were encapsulated into the hydrogel scaffolds with or without HA-PA and cultured in osteogenic medium up to 3 weeks. The result showed that HA-PA could help the deposition of bone marker proteins. The hydrogel-hydroxyapatite composite material was also employed as the protein controlled release carrier, which gave prolonged protein release. The second polymer was synthesized based on chondroitin sulfate, the polysaccharide, which is the main component of extracellular matrix of cartilage tissue. The swelling behavior, degradation profile, mechanical properties and biocompatibility of the hydrogel scaffolds based on chondroitin sulfate were then evaluated. In order to study the effects of chondroitin sulfate on the redifferentiation of dedifferentiated chondrocytes, passage 3 (P3) chondrocytes were encapsulated into the hydrogel scaffolds with or without chondroitin sulfate. After 3-week cultivation of the constructs in chondrocytes medium, the result showed improved GAG production with 25% (w/w) chondroitin sulfate in the gel. Finally the orientational alignment phenomenon of the macromer during photopolymerization process was discussed.
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650 4 $a Engineering, Biomedical. $3 1017684
650 4 $a Chemistry, Polymer. $3 1018428
650 4 $a Biology, Cell. $3 1017686
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710 2 0 $a The Johns Hopkins University. $3 1017431
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