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Development of CD1d-restricted Valph...

Wei, Datsen George.

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Development of CD1d-restricted Valpha14+ NKT cells.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Development of CD1d-restricted Valpha14+ NKT cells./
Author:	Wei, Datsen George.
Description:	164 p.
Notes:	Source: Dissertation Abstracts International, Volume: 67-01, Section: B, page: 0110.
Contained By:	Dissertation Abstracts International67-01B.
Subject:	Biology, Molecular. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3206289
ISBN:	9780542523564

Development of CD1d-restricted Valpha14+ NKT cells.
Wei, Datsen George.

Development of CD1d-restricted Valpha14+ NKT cells. - 164 p.

Source: Dissertation Abstracts International, Volume: 67-01, Section: B, page: 0110.

Thesis (Ph.D.)--Princeton University, 2006.

During thymic development, NKT cells diverge from the pathways of conventional CD4 and CD8 T cells at the CD4+CD8+ double-positive (DP) stage. This corresponds to the stage at which their semi-invariant Valpha14 TCR interacts with the MHC I-like molecule, CD1d, complexed with the self-glycolipid iGb3.

ISBN: 9780542523564Subjects--Topical Terms:

1017719
Biology, Molecular.

Development of CD1d-restricted Valpha14+ NKT cells.
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100 1 $a Wei, Datsen George. $3 1909539
245 1 0 $a Development of CD1d-restricted Valpha14+ NKT cells.
300 $a 164 p.
500 $a Source: Dissertation Abstracts International, Volume: 67-01, Section: B, page: 0110.
500 $a Adviser: Albert Bendelac.
502 $a Thesis (Ph.D.)--Princeton University, 2006.
520 $a During thymic development, NKT cells diverge from the pathways of conventional CD4 and CD8 T cells at the CD4+CD8+ double-positive (DP) stage. This corresponds to the stage at which their semi-invariant Valpha14 TCR interacts with the MHC I-like molecule, CD1d, complexed with the self-glycolipid iGb3.
520 $a In this project, I hypothesized that the conditions of TCR stimulation of NKT precursors must differ from those of conventional T cells. Using transgenic approaches to redirect CD1d expression in different cell types, I demonstrated that cortical DP thymocytes, rather than thymic epithelial cells, were both necessary and sufficient for NKT cell development. Additional interactions with CD1d expressed on other cell types were not essential, but they influenced subtle aspects of the terminal differentiation and reactivity of NKT cells.
520 $a Using a modified Valpha14 TCR transgenic system, I demonstrated the agonist nature of the CD1d/iGb3 ligand, another unusual feature distinguishing NKT cell development from MHC/peptide-restricted conventional T cell development. Further, these Valpha14 transgenic cells allowed for a dissection of the contribution of the Vbeta repertoire associated with the canonical Valpha14 TCR a chain. The results indicated a clear hierarchy of affinity with Vbeta7 > Vbeta8 > Vbeta2.
520 $a Collectively, these results identify two distinct features of NKT cell selection, the agonistic nature of Valpha14 TCR signals and the homotypic nature of thymocyte interactions (DP-DP), which may both contribute to the unusual signaling events leading to the NKT developmental pathway.
590 $a School code: 0181.
650 4 $a Biology, Molecular. $3 1017719
650 4 $a Health Sciences, Immunology. $3 1017716
690 $a 0307
690 $a 0982
710 2 0 $a Princeton University. $3 645579
773 0 $t Dissertation Abstracts International $g 67-01B.
790 1 0 $a Bendelac, Albert, $e advisor
790 $a 0181
791 $a Ph.D.
792 $a 2006
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