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Early embryonic apoptosis in the pur...

Vega Thurber, Rebecca Lisette.

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Early embryonic apoptosis in the purple sea urchin, Strongylocentrotus purpuratus: Developmental timing, control, and responses to environmental disruption.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Early embryonic apoptosis in the purple sea urchin, Strongylocentrotus purpuratus: Developmental timing, control, and responses to environmental disruption./
作者:	Vega Thurber, Rebecca Lisette.
面頁冊數:	93 p.
附註:	Source: Dissertation Abstracts International, Volume: 66-11, Section: B, page: 5774.
Contained By:	Dissertation Abstracts International66-11B.
標題:	Biology, Cell. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3197523
ISBN:	9780542432217

Early embryonic apoptosis in the purple sea urchin, Strongylocentrotus purpuratus: Developmental timing, control, and responses to environmental disruption.
Vega Thurber, Rebecca Lisette.

Early embryonic apoptosis in the purple sea urchin, Strongylocentrotus purpuratus: Developmental timing, control, and responses to environmental disruption. - 93 p.

Source: Dissertation Abstracts International, Volume: 66-11, Section: B, page: 5774.

Thesis (Ph.D.)--Stanford University, 2006.

This dissertation characterizes a novel link between apoptosis and efflux transporters in early sea urchin development. Using a cell biological framework I have demonstrated that while embryos of the sea urchin Strongylocentrotus purpuratus are highly resistant to stress-induced apoptosis, disruption of the efflux transporter system circumvents or directly abolishes this resistance. In addition this dissertation has demonstrated that while apoptosis is stage dependent, occurs in low frequency, and is unnecessary for normal urchin development, it is advantageous during times of stress, providing urchin embryos a sensitive pathway to eliminate damaged cells in early development. This study also found that inducible apoptosis occurs in a temporally predictable fashion, peaking around the hatching stage. These findings confirm that chemo-sensitization via transporter inhibition has real embryological consequences. In addition, I have shown for the first time that small subtle variations in transporter substrate sensitivity significantly affect embryo toxin susceptibility, a result that has important implications for embryo health and survivorship.

ISBN: 9780542432217Subjects--Topical Terms:

1017686
Biology, Cell.

Early embryonic apoptosis in the purple sea urchin, Strongylocentrotus purpuratus: Developmental timing, control, and responses to environmental disruption.
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520 $a This dissertation characterizes a novel link between apoptosis and efflux transporters in early sea urchin development. Using a cell biological framework I have demonstrated that while embryos of the sea urchin Strongylocentrotus purpuratus are highly resistant to stress-induced apoptosis, disruption of the efflux transporter system circumvents or directly abolishes this resistance. In addition this dissertation has demonstrated that while apoptosis is stage dependent, occurs in low frequency, and is unnecessary for normal urchin development, it is advantageous during times of stress, providing urchin embryos a sensitive pathway to eliminate damaged cells in early development. This study also found that inducible apoptosis occurs in a temporally predictable fashion, peaking around the hatching stage. These findings confirm that chemo-sensitization via transporter inhibition has real embryological consequences. In addition, I have shown for the first time that small subtle variations in transporter substrate sensitivity significantly affect embryo toxin susceptibility, a result that has important implications for embryo health and survivorship.
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