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Regulation of hepatitis B virus gene...

Zheng, Yanyan.

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Regulation of hepatitis B virus gene expression and replication.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Regulation of hepatitis B virus gene expression and replication./
Author:	Zheng, Yanyan.
Description:	144 p.
Notes:	Source: Dissertation Abstracts International, Volume: 66-06, Section: B, page: 2949.
Contained By:	Dissertation Abstracts International66-06B.
Subject:	Biology, Microbiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3180394
ISBN:	0542204851

Regulation of hepatitis B virus gene expression and replication.
Zheng, Yanyan.

Regulation of hepatitis B virus gene expression and replication. - 144 p.

Source: Dissertation Abstracts International, Volume: 66-06, Section: B, page: 2949.

Thesis (Ph.D.)--University of Southern California, 2005.

Hepatitis B virus (HBV) is an important etiological factor for liver diseases. The study presented in this dissertation focuses on the regulation of HBV life cycle by various host factors.

ISBN: 0542204851Subjects--Topical Terms:

1017734
Biology, Microbiology.

Regulation of hepatitis B virus gene expression and replication.
LDR:03007nmm 2200325 4500 001 1818944
005 20061003091756.5
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020 $a 0542204851
035 $a (UnM)AAI3180394
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040 $a UnM $c UnM
100 1 $a Zheng, Yanyan. $3 1908247
245 1 0 $a Regulation of hepatitis B virus gene expression and replication.
300 $a 144 p.
500 $a Source: Dissertation Abstracts International, Volume: 66-06, Section: B, page: 2949.
500 $a Adviser: Jing-Hsiung James Ou.
502 $a Thesis (Ph.D.)--University of Southern California, 2005.
520 $a Hepatitis B virus (HBV) is an important etiological factor for liver diseases. The study presented in this dissertation focuses on the regulation of HBV life cycle by various host factors.
520 $a HNF4 and HNF1 are two important liver-specific transcription factors. A natural occurring double mutant in HBV core promoter (1765 A to T and 1767 G to A) creates a binding site for the transcription factor HNF1 and a mutant form of X protein. It also selectively abolishes the binding of several nuclear receptors without affecting that of HNF4. My study showed that HNF4 could stimulate the expression of the precore RNA and the core RNA from the core promoter of both the wild-type (WT) HBV and the double mutant. In contrast, HNF1 suppressed the precore RNA expression of the double mutant but not the wild type. X protein did not affect the HNF4 activity on the core promoter and affected the HNF1 activity on the core promoter of only the double mutant.
520 $a Two host kinases, SRPKI and SRPK2, could suppress HBV replication by reducing the packaging efficiency of the pgRNA without affecting the formation of the core particles. This inhibition is independent of the kinase activity of SRPKs or the phosphorylation of the core protein.
520 $a The effect of Ras signaling pathway on the replication of HBV was also studied in this dissertation. The Ras-ERK pathway could suppress the replication of HBV in both Huh7 and HepG2 cells. This suppression was independent of the X protein and most likely occurred at the transcription level. Further study with deletion-mapping analysis showed the existence of multiple Ras-responsive elements in HBV core promoter and its upstream ENI and ENII enhancers.
520 $a The studies presented in this dissertation thus indicated complicated regulation of Hepatitis B Virus life cycle by the host cellular factors. These studies have led to a better understanding of the cross talk between the virus and the host. Further work in this area will shed light on the design of new drugs, which will eventually lead to the cure of hepatitis B.
590 $a School code: 0208.
650 4 $a Biology, Microbiology. $3 1017734
650 4 $a Biology, Molecular. $3 1017719
690 $a 0410
690 $a 0307
710 2 0 $a University of Southern California. $3 700129
773 0 $t Dissertation Abstracts International $g 66-06B.
790 1 0 $a Ou, Jing-Hsiung James, $e advisor
790 $a 0208
791 $a Ph.D.
792 $a 2005
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3180394