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Magnetic resonance imaging applied t...

Sorger, Jonathan Michael.

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Magnetic resonance imaging applied to cardiac pathologies: Methods for diagnoses and delivery of therapy.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Magnetic resonance imaging applied to cardiac pathologies: Methods for diagnoses and delivery of therapy./
Author:	Sorger, Jonathan Michael.
Description:	156 p.
Notes:	Source: Dissertation Abstracts International, Volume: 65-04, Section: B, page: 1973.
Contained By:	Dissertation Abstracts International65-04B.
Subject:	Engineering, Biomedical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3130791
ISBN:	0496780395

Magnetic resonance imaging applied to cardiac pathologies: Methods for diagnoses and delivery of therapy.
Sorger, Jonathan Michael.

Magnetic resonance imaging applied to cardiac pathologies: Methods for diagnoses and delivery of therapy. - 156 p.

Source: Dissertation Abstracts International, Volume: 65-04, Section: B, page: 1973.

Thesis (Ph.D.)--The Johns Hopkins University, 2004.

Advances in imaging equipment, medical devices and pharmaceuticals have led to improved diagnoses and treatment of cardiovascular disease. While the application of electrical stimuli has been proven to improve cardiac function in patients with conduction abnormalities, genetic and cellular therapies have recently shown potential in regenerative medicine.

ISBN: 0496780395Subjects--Topical Terms:

1017684
Engineering, Biomedical.

Magnetic resonance imaging applied to cardiac pathologies: Methods for diagnoses and delivery of therapy.
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100 1 $a Sorger, Jonathan Michael. $3 1907236
245 1 0 $a Magnetic resonance imaging applied to cardiac pathologies: Methods for diagnoses and delivery of therapy.
300 $a 156 p.
500 $a Source: Dissertation Abstracts International, Volume: 65-04, Section: B, page: 1973.
500 $a Adviser: Elliot R. McVeigh.
502 $a Thesis (Ph.D.)--The Johns Hopkins University, 2004.
520 $a Advances in imaging equipment, medical devices and pharmaceuticals have led to improved diagnoses and treatment of cardiovascular disease. While the application of electrical stimuli has been proven to improve cardiac function in patients with conduction abnormalities, genetic and cellular therapies have recently shown potential in regenerative medicine.
520 $a Since scientists first applied external electrical impulses to pace the heart in 1952, a growing body of knowledge related to cardiac electrophysiology has accumulated. While the clinical benefits of pacemakers cannot be understated, the mechanical effects of pacing have only recently been described in detail. A more thorough understanding of the impact of pacing on cardiac mechanics will help improve future pacemaker designs. Accordingly, one of the goals of this work was to examine how pacing the heart from different locations affects the rotational dynamics of heart function.
520 $a The torsion of the left ventricle was investigated under three different protocols: (1) Right atrial pacing, (2) Right ventricular pacing and (3) Simultaneous pacing from the right ventricular apex and LV base. It was shown that while biventricular pacing increases the synchrony of contraction, it does not restore the normal physiologic twist patterns of the heart.
520 $a While pacing is an established clinical technique for the treatment of electrical abnormalities, recent discoveries in genetics and cell biology have the potential to change the way that physicians care for patients with heart disease. Current methods of clinical treatment of coronary artery disease focus on restoring blood flow to ischemic regions by opening blocked arteries through surgical and catheter-based procedures. The ability to reduce the amount of tissue damaged as a result of cardiac disease or even regenerate new myocardium would go one step beyond current therapies and has direct clinical implications.
520 $a Delivery of genes and/or cell therapy to the affected tissue may play a large role in new treatments. Increasing the accuracy of noninvasive delivery of therapeutic material to the region of interest is an important step in gaining clinical acceptance of such methods. While some treatments can be delivered systemically, local delivery often results in a lower required dosage and fewer side effects. This work demonstrates the feasibility of using real-time magnetic resonance imaging to guide the injection of such materials into target tissues.
520 $a It is possible that systemically delivered materials will show clinical benefit, reducing the need for invasive delivery procedures. (Abstract shortened by UMI.)
590 $a School code: 0098.
650 4 $a Engineering, Biomedical. $3 1017684
650 4 $a Health Sciences, Pathology. $3 1017854
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690 $a 0571
710 2 0 $a The Johns Hopkins University. $3 1017431
773 0 $t Dissertation Abstracts International $g 65-04B.
790 1 0 $a McVeigh, Elliot R., $e advisor
790 $a 0098
791 $a Ph.D.
792 $a 2004
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3130791