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Putative pacemaker cells and the reg...

Bryant, Damani Nabate-Yero.

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Putative pacemaker cells and the regulation of circadian rhythmicity by the suprachiasmatic nucleus of the hypothalamus.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Putative pacemaker cells and the regulation of circadian rhythmicity by the suprachiasmatic nucleus of the hypothalamus./
Author:	Bryant, Damani Nabate-Yero.
Description:	113 p.
Notes:	Source: Dissertation Abstracts International, Volume: 61-07, Section: B, page: 3893.
Contained By:	Dissertation Abstracts International61-07B.
Subject:	Psychology, Psychobiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9981596
ISBN:	0599880740

Putative pacemaker cells and the regulation of circadian rhythmicity by the suprachiasmatic nucleus of the hypothalamus.
Bryant, Damani Nabate-Yero.

Putative pacemaker cells and the regulation of circadian rhythmicity by the suprachiasmatic nucleus of the hypothalamus. - 113 p.

Source: Dissertation Abstracts International, Volume: 61-07, Section: B, page: 3893.

Thesis (Ph.D.)--State University of New York at Binghamton, 2000.

The suprachiasmatic nucleus (SCN) of the hypothalamus is the site of the light entrainable circadian pacemaker (Moore-ede et al., 1982). Accumulating evidence suggests that there are putative pacemaker cells in the SCN that are necessary and sufficient for the expression of circadian rhythmicity. This series of experiments was undertaken in order to identify putative pacemaker cells in the rat SCN. Cells expressing the transcription factor phospho-CREB (pCREB) and the calcium binding protein calretinin (CR) were assessed in terms of two prerequisites. The first is the capacity to oscillate in the SCN in a circadian manner under constant conditions. The second prerequisite is the capacity to respond in a phase dependent manner to photic stimuli. Unbiased estimates of pCREB and CR-ir cell number indicate that neither population varies in a circadian manner under constant conditions. However, pCREB but not CR exhibits statistically significant reductions in cell number subsequent to repeated exposure to light for the duration of the active phase. The apparent increase in pCREB immunoreactivity in the ventral SCN at circadian time (CT) 18 was not significantly different from any of the other sampling times (CT's 0, 6 and 12). Ultrastructural examination indicated that increased immunoreactivity observed in the ventral SCN may be produced by intense pCREB-ir in the nuclear chromatin of astrocytes and oligodendroglia. In summary, neither pCREB nor CR are a useful index of pacemaker cell activity. As such, findings of this series of studies are discussed in terms of the idea that rhythmicity is generated by interacting cell populations in the SCN rather than one circumscribed population.

ISBN: 0599880740Subjects--Topical Terms:

1017821
Psychology, Psychobiology.

Putative pacemaker cells and the regulation of circadian rhythmicity by the suprachiasmatic nucleus of the hypothalamus.
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100 1 $a Bryant, Damani Nabate-Yero. $3 1907194
245 1 0 $a Putative pacemaker cells and the regulation of circadian rhythmicity by the suprachiasmatic nucleus of the hypothalamus.
300 $a 113 p.
500 $a Source: Dissertation Abstracts International, Volume: 61-07, Section: B, page: 3893.
500 $a Adviser: Maria-Teresa Romero.
502 $a Thesis (Ph.D.)--State University of New York at Binghamton, 2000.
520 $a The suprachiasmatic nucleus (SCN) of the hypothalamus is the site of the light entrainable circadian pacemaker (Moore-ede et al., 1982). Accumulating evidence suggests that there are putative pacemaker cells in the SCN that are necessary and sufficient for the expression of circadian rhythmicity. This series of experiments was undertaken in order to identify putative pacemaker cells in the rat SCN. Cells expressing the transcription factor phospho-CREB (pCREB) and the calcium binding protein calretinin (CR) were assessed in terms of two prerequisites. The first is the capacity to oscillate in the SCN in a circadian manner under constant conditions. The second prerequisite is the capacity to respond in a phase dependent manner to photic stimuli. Unbiased estimates of pCREB and CR-ir cell number indicate that neither population varies in a circadian manner under constant conditions. However, pCREB but not CR exhibits statistically significant reductions in cell number subsequent to repeated exposure to light for the duration of the active phase. The apparent increase in pCREB immunoreactivity in the ventral SCN at circadian time (CT) 18 was not significantly different from any of the other sampling times (CT's 0, 6 and 12). Ultrastructural examination indicated that increased immunoreactivity observed in the ventral SCN may be produced by intense pCREB-ir in the nuclear chromatin of astrocytes and oligodendroglia. In summary, neither pCREB nor CR are a useful index of pacemaker cell activity. As such, findings of this series of studies are discussed in terms of the idea that rhythmicity is generated by interacting cell populations in the SCN rather than one circumscribed population.
590 $a School code: 0792.
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773 0 $t Dissertation Abstracts International $g 61-07B.
790 1 0 $a Romero, Maria-Teresa, $e advisor
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